Genetics of familial renal cancers.

Eamonn Maher

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    Renal cell carcinoma (RCC) is a heterogeneous disorder. A variety of histopathological subtypes occur, and the molecular mechanisms associated with these subtypes can differ. Only a small fraction of all RCC is accounted for by inherited cases (e.g. von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, hereditary leiomyomatosis renal cell cancer), but such cases can pose specific clinical management issues and offer opportunities for early cancer detection and prevention. Furthermore, inherited RCC syndromes have provided important paradigms to study the molecular basis of renal tumourigenesis. The identification of molecular mechanisms of carcinogenesis in inherited RCC syndromes should lead to novel approaches to personalized therapeutics.
    Original languageEnglish
    Pages (from-to)e21-6
    JournalNephron. Experimental nephrology
    Volume118
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2011

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