TY - JOUR
T1 - Genetically predicted 17beta-estradiol and cardiovascular risk factors in women
T2 - a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study
AU - Au Yeung, Shiu Lun
AU - Cheng, Kar Keung
AU - Zhao, Jie
AU - Zhang, Weisen
AU - Jiang, Chaoqiang
AU - Lam, Tai Hing
AU - Leung, Gabriel Matthew
AU - Schooling, C Mary
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/2/4
Y1 - 2016/2/4
N2 - PURPOSE: The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies.METHODS: We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong (n = 236).RESULTS: Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (-0.01, 95% confidence interval = -1.34 to 1.31).CONCLUSIONS: Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.
AB - PURPOSE: The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies.METHODS: We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong (n = 236).RESULTS: Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (-0.01, 95% confidence interval = -1.34 to 1.31).CONCLUSIONS: Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.
KW - Estrogen
KW - Cardiovascular risk factors
KW - Mendelian randomization analysis
KW - Chinese
KW - Women
U2 - 10.1016/j.annepidem.2016.01.005
DO - 10.1016/j.annepidem.2016.01.005
M3 - Article
C2 - 26907540
SN - 1047-2797
JO - Annals of Epidemiology
JF - Annals of Epidemiology
ER -
