Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

ML Hamshere; EK Green; Ian Jones; Lisa Jones; V Moskvina; G Kirov; D Grozeva; I Nikolov; D Vukcevic; S Caesar; Katherine Gordon-Smith; C Fraser; E Russell; G Breen; D St Clair; DA Collier; AH Young; IN Ferrier; A Farmer; P McGuffin; PA Holmans; MJ Owen; MC O'Donovan; N Craddock

doi:10.1192/bjp.bp.108.061424

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

ML Hamshere, EK Green, Ian Jones, Lisa Jones, V Moskvina, G Kirov, D Grozeva, I Nikolov, D Vukcevic, S Caesar, Katherine Gordon-Smith, C Fraser, E Russell, G Breen, D St Clair, DA Collier, AH Young, IN Ferrier, A Farmer, P McGuffinPA Holmans, MJ Owen, MC O'Donovan, N Craddock

Birmingham Medical School

Research output: Contribution to journal › Article

81 Citations (Scopus)

Abstract

Background Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. Aims To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case-control bipolar disorder sample. Method We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, comprising 1868 individuals with bipolar disorder and 2938 controls genotyped for 276122 single nucleotide polymorphisms (SNPs) that met stringent criteria for genotype quality. For each SNP we performed a test of association (bipolar disorder group v. control group) and used the number of associated independent SNPs statistically significant at P

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	British Journal of Psychiatry
Volume	195
Issue number	1
DOIs	https://doi.org/10.1192/bjp.bp.108.061424
Publication status	Published - 1 Jul 2009

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10.1192/bjp.bp.108.061424

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Hamshere, ML., Green, EK., Jones, I., Jones, L., Moskvina, V., Kirov, G., Grozeva, D., Nikolov, I., Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Breen, G., St Clair, D., Collier, DA., Young, AH., Ferrier, IN., Farmer, A., ... Craddock, N. (2009). Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry, 195(1), 23-29. https://doi.org/10.1192/bjp.bp.108.061424

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title = "Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept",

abstract = "Background Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. Aims To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case-control bipolar disorder sample. Method We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, comprising 1868 individuals with bipolar disorder and 2938 controls genotyped for 276122 single nucleotide polymorphisms (SNPs) that met stringent criteria for genotype quality. For each SNP we performed a test of association (bipolar disorder group v. control group) and used the number of associated independent SNPs statistically significant at P",

author = "ML Hamshere and EK Green and Ian Jones and Lisa Jones and V Moskvina and G Kirov and D Grozeva and I Nikolov and D Vukcevic and S Caesar and Katherine Gordon-Smith and C Fraser and E Russell and G Breen and {St Clair}, D and DA Collier and AH Young and IN Ferrier and A Farmer and P McGuffin and PA Holmans and MJ Owen and MC O'Donovan and N Craddock",

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Hamshere, ML, Green, EK, Jones, I, Jones, L, Moskvina, V, Kirov, G, Grozeva, D, Nikolov, I, Vukcevic, D, Caesar, S, Gordon-Smith, K, Fraser, C, Russell, E, Breen, G, St Clair, D, Collier, DA, Young, AH, Ferrier, IN, Farmer, A, McGuffin, P, Holmans, PA, Owen, MJ, O'Donovan, MC & Craddock, N 2009, 'Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept', British Journal of Psychiatry, vol. 195, no. 1, pp. 23-29. https://doi.org/10.1192/bjp.bp.108.061424

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T1 - Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

AU - Hamshere, ML

AU - Green, EK

AU - Jones, Ian

AU - Jones, Lisa

AU - Moskvina, V

AU - Kirov, G

AU - Grozeva, D

AU - Nikolov, I

AU - Vukcevic, D

AU - Caesar, S

AU - Gordon-Smith, Katherine

AU - Fraser, C

AU - Russell, E

AU - Breen, G

AU - St Clair, D

AU - Collier, DA

AU - Young, AH

AU - Ferrier, IN

AU - Farmer, A

AU - McGuffin, P

AU - Holmans, PA

AU - Owen, MJ

AU - O'Donovan, MC

AU - Craddock, N

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. Aims To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case-control bipolar disorder sample. Method We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, comprising 1868 individuals with bipolar disorder and 2938 controls genotyped for 276122 single nucleotide polymorphisms (SNPs) that met stringent criteria for genotype quality. For each SNP we performed a test of association (bipolar disorder group v. control group) and used the number of associated independent SNPs statistically significant at P

AB - Background Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. Aims To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case-control bipolar disorder sample. Method We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, comprising 1868 individuals with bipolar disorder and 2938 controls genotyped for 276122 single nucleotide polymorphisms (SNPs) that met stringent criteria for genotype quality. For each SNP we performed a test of association (bipolar disorder group v. control group) and used the number of associated independent SNPs statistically significant at P

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Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

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