Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis

S Xiao; C Sato; T Kawarai; Emily Goodall; Hardev Pall; LH Zinman; J Robertson; Karen Morrison; K Rogaeva

doi:10.1016/j.neurobiolaging.2007.02.022

Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis

S Xiao, C Sato, T Kawarai, Emily Goodall, Hardev Pall, LH Zinman, J Robertson, Karen Morrison, K Rogaeva

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.

Original language	English
Pages (from-to)	1279-1282
Number of pages	4
Journal	Neurobiology of Aging
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.02.022
Publication status	Published - 1 Mar 2007

Keywords

amyotrophic lateral sclerosis
progranulin
single nucleotide polymorphism
risk factor

Access to Document

10.1016/j.neurobiolaging.2007.02.022

Cite this

@article{418c7693aa944f9e8013fd6a2a42b20b,

title = "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis",

abstract = "There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.",

keywords = "amyotrophic lateral sclerosis, progranulin, single nucleotide polymorphism, risk factor",

author = "S Xiao and C Sato and T Kawarai and Emily Goodall and Hardev Pall and LH Zinman and J Robertson and Karen Morrison and K Rogaeva",

year = "2007",

month = mar,

day = "1",

doi = "10.1016/j.neurobiolaging.2007.02.022",

language = "English",

volume = "29",

pages = "1279--1282",

journal = "Neurobiology of Aging",

publisher = "Elsevier",

number = "8",

}

TY - JOUR

T1 - Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis

AU - Xiao, S

AU - Sato, C

AU - Kawarai, T

AU - Goodall, Emily

AU - Pall, Hardev

AU - Zinman, LH

AU - Robertson, J

AU - Morrison, Karen

AU - Rogaeva, K

PY - 2007/3/1

Y1 - 2007/3/1

N2 - There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.

AB - There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.

KW - amyotrophic lateral sclerosis

KW - progranulin

KW - single nucleotide polymorphism

KW - risk factor

U2 - 10.1016/j.neurobiolaging.2007.02.022

DO - 10.1016/j.neurobiolaging.2007.02.022

M3 - Article

C2 - 17383054

VL - 29

SP - 1279

EP - 1282

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 8

ER -

Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis

Abstract

Keywords

Access to Document

Fingerprint

Cite this