Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis

S Xiao, C Sato, T Kawarai, Emily Goodall, Hardev Pall, LH Zinman, J Robertson, Karen Morrison, K Rogaeva

    Research output: Contribution to journalArticle

    9 Citations (Scopus)


    There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.
    Original languageEnglish
    Pages (from-to)1279-1282
    Number of pages4
    JournalNeurobiology of Aging
    Issue number8
    Publication statusPublished - 1 Mar 2007


    • amyotrophic lateral sclerosis
    • progranulin
    • single nucleotide polymorphism
    • risk factor


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