Genetic control of programmed cell death (apoptosis) in Drosophila

Dongbin Xu, Sarah E Woodfield, Tom V Lee, Yun Fan, Christian Antonio, Andreas Bergmann

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)


Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
Original languageEnglish
Pages (from-to)78-90
Number of pages13
Issue number1
Publication statusPublished - 2009


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