Generation of neuroprogenitor-like cells from adult mammalian bone marrow stromal cells in vitro

A. P. Croft, Stefan A. Przyborski

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

Recently, it has been proposed that bone marrow stromal cells (BMSCs) have a broader capacity for differentiation than previously contemplated. In vitro studies have indicated that BMSCs may have the capacity to differentiate into neuroectodermal-like cells in response to various growth conditions, including those commonly used to maintain and differentiate cultures of primary neural stem cells (NSCs). Interpreting the wealth of data on this subject has been difficult because of variation in the starting cell population and the differences between the methods used to induce their differentiation. Here we evaluate how cultures of expanded BMSCs with a consistent immunophenotype respond to a variety of growth conditions and induction agents and review their ability to form neural-like derivatives. In addition, we report on some modifications to previously published techniques for the generation of neural-like cells from BMSCs in vitro.

Original languageEnglish
Pages (from-to)409-420
Number of pages12
JournalStem Cells and Development
Volume13
Issue number4
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Generation of neuroprogenitor-like cells from adult mammalian bone marrow stromal cells in vitro'. Together they form a unique fingerprint.

Cite this