Generation and repair of thymic epithelial cells

Graham Anderson; Emilie J Cosway; Kieran D James; Izumi Ohigashi; Yousuke Takahama

doi:10.1084/jem.20230894

Generation and repair of thymic epithelial cells

Graham Anderson^*
, Emilie J Cosway
, Kieran D James
, Izumi Ohigashi
, Yousuke Takahama

^*Corresponding author for this work

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

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Abstract

In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.

Original language	English
Article number	e20230894
Number of pages	17
Journal	The Journal of Experimental Medicine
Volume	221
Issue number	10
Early online date	9 Jul 2024
DOIs	https://doi.org/10.1084/jem.20230894
Publication status	Published - 7 Oct 2024

Bibliographical note

Keywords

Thymus Gland/cytology
Epithelial Cells/cytology
Animals
Humans
Cell Differentiation
Regeneration/physiology
Thymocytes/cytology

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10.1084/jem.20230894Licence: Creative Commons: Attribution (CC BY)

AndersonG2024GenerationFinal published version, 2.06 MBLicence: Creative Commons: Attribution (CC BY)

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Correction: Generation and repair of thymic epithelial cells
Anderson, G., Cosway, E., James, K., Ohigashi, I. & Takahama, Y., 7 Oct 2024, In: The Journal of Experimental Medicine. 221, 10, e2023089409042024c.
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Targeting New Mechanisms In The Control Of Thymus Function To Restore Balanced T-cell Production
Anderson, G. (Principal Investigator)
Medical Research Council
1/01/21 → 31/12/27
Project: Research Councils

Cite this

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title = "Generation and repair of thymic epithelial cells",

abstract = "In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.",

keywords = "Thymus Gland/cytology, Epithelial Cells/cytology, Animals, Humans, Cell Differentiation, Regeneration/physiology, Thymocytes/cytology",

author = "Graham Anderson and Cosway, \{Emilie J\} and James, \{Kieran D\} and Izumi Ohigashi and Yousuke Takahama",

note = "{\textcopyright} 2024 Anderson et al.",

year = "2024",

month = oct,

day = "7",

doi = "10.1084/jem.20230894",

language = "English",

volume = "221",

journal = "The Journal of Experimental Medicine",

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T1 - Generation and repair of thymic epithelial cells

AU - Anderson, Graham

AU - Cosway, Emilie J

AU - James, Kieran D

AU - Ohigashi, Izumi

AU - Takahama, Yousuke

PY - 2024/10/7

Y1 - 2024/10/7

N2 - In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.

AB - In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.

KW - Thymus Gland/cytology

KW - Epithelial Cells/cytology

KW - Animals

KW - Humans

KW - Cell Differentiation

KW - Regeneration/physiology

KW - Thymocytes/cytology

U2 - 10.1084/jem.20230894

DO - 10.1084/jem.20230894

M3 - Review article

C2 - 38980292

SN - 0022-1007

VL - 221

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

IS - 10

M1 - e20230894

ER -

Generation and repair of thymic epithelial cells

Abstract

Bibliographical note

Keywords

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Research output

Correction: Generation and repair of thymic epithelial cells

Projects

Targeting New Mechanisms In The Control Of Thymus Function To Restore Balanced T-cell Production

Cite this