Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins

Joseph R Shaw; John K Colbourne; Jennifer C Davey; Stephen P Glaholt; Thomas H Hampton; Celia Y Chen; Carol L Folt; Joshua W Hamilton

doi:10.1186/1471-2164-8-477

Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins

Joseph R Shaw, John K Colbourne, Jennifer C Davey, Stephen P Glaholt, Thomas H Hampton, Celia Y Chen, Carol L Folt, Joshua W Hamilton

Biosciences

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Abstract

Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. A first generation cDNA microarray was developed for the environmental indicator species Daphnia pulex, to identify genes whose regulation is modulated following exposure to the metal stressor cadmium. Our experiments revealed interesting changes in gene transcription that suggest their biological roles and their potentially toxicological features in responding to this important environmental contaminant.

Original language	English
Article number	477
Journal	BMC Genomics
Volume	8
DOIs	https://doi.org/10.1186/1471-2164-8-477
Publication status	Published - 21 Dec 2007

Keywords

Animals
Biological Markers
Cadmium
DNA, Complementary
Daphnia
Databases, Genetic
Dose-Response Relationship, Drug
Environmental Monitoring
Gene Expression Profiling
Gene Expression Regulation
Genome
Metallothionein
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction
Water Pollutants, Chemical

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10.1186/1471-2164-8-477

Shaw_et_al_Gene_response_profiles_BMC_Genomics_2007
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Checked July 2015
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title = "Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins",

abstract = "Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. A first generation cDNA microarray was developed for the environmental indicator species Daphnia pulex, to identify genes whose regulation is modulated following exposure to the metal stressor cadmium. Our experiments revealed interesting changes in gene transcription that suggest their biological roles and their potentially toxicological features in responding to this important environmental contaminant.",

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author = "Shaw, {Joseph R} and Colbourne, {John K} and Davey, {Jennifer C} and Glaholt, {Stephen P} and Hampton, {Thomas H} and Chen, {Celia Y} and Folt, {Carol L} and Hamilton, {Joshua W}",

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doi = "10.1186/1471-2164-8-477",

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T1 - Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins

AU - Shaw, Joseph R

AU - Colbourne, John K

AU - Davey, Jennifer C

AU - Glaholt, Stephen P

AU - Hampton, Thomas H

AU - Chen, Celia Y

AU - Folt, Carol L

AU - Hamilton, Joshua W

PY - 2007/12/21

Y1 - 2007/12/21

N2 - Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. A first generation cDNA microarray was developed for the environmental indicator species Daphnia pulex, to identify genes whose regulation is modulated following exposure to the metal stressor cadmium. Our experiments revealed interesting changes in gene transcription that suggest their biological roles and their potentially toxicological features in responding to this important environmental contaminant.

AB - Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. A first generation cDNA microarray was developed for the environmental indicator species Daphnia pulex, to identify genes whose regulation is modulated following exposure to the metal stressor cadmium. Our experiments revealed interesting changes in gene transcription that suggest their biological roles and their potentially toxicological features in responding to this important environmental contaminant.

KW - Animals

KW - Biological Markers

KW - Cadmium

KW - DNA, Complementary

KW - Daphnia

KW - Databases, Genetic

KW - Dose-Response Relationship, Drug

KW - Environmental Monitoring

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Genome

KW - Metallothionein

KW - Molecular Sequence Data

KW - Oligonucleotide Array Sequence Analysis

KW - Phylogeny

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Water Pollutants, Chemical

U2 - 10.1186/1471-2164-8-477

DO - 10.1186/1471-2164-8-477

M3 - Article

C2 - 18154678

SN - 1471-2164

VL - 8

JO - BMC Genomics

JF - BMC Genomics

M1 - 477

ER -

Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins

Abstract

Keywords

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