Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins

Joseph R Shaw, John K Colbourne, Jennifer C Davey, Stephen P Glaholt, Thomas H Hampton, Celia Y Chen, Carol L Folt, Joshua W Hamilton

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)
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Abstract

Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. A first generation cDNA microarray was developed for the environmental indicator species Daphnia pulex, to identify genes whose regulation is modulated following exposure to the metal stressor cadmium. Our experiments revealed interesting changes in gene transcription that suggest their biological roles and their potentially toxicological features in responding to this important environmental contaminant.
Original languageEnglish
Article number477
JournalBMC Genomics
Volume8
DOIs
Publication statusPublished - 21 Dec 2007

Keywords

  • Animals
  • Biological Markers
  • Cadmium
  • DNA, Complementary
  • Daphnia
  • Databases, Genetic
  • Dose-Response Relationship, Drug
  • Environmental Monitoring
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genome
  • Metallothionein
  • Molecular Sequence Data
  • Oligonucleotide Array Sequence Analysis
  • Phylogeny
  • Reverse Transcriptase Polymerase Chain Reaction
  • Water Pollutants, Chemical

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