Gating of memory encoding of time-delayed cross-frequency MEG networks revealed by graph filtration based on persistent homology

Jarang Hahm, Hyekyoung Lee, Hyojin Park, Eunjoo Kang, Yu Kyeong Kim, Chun Kee Chung, Hyejin Kang, Dong Soo Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
160 Downloads (Pure)

Abstract

To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative coupling between the left superior occipital (cue-alpha) and the left dorsolateral superior frontal gyri (item-gamma) on permutation test, where the coupling was stronger in R than NR. In good memory performers (R-hits minus false alarm), the coupling was stronger in R than NR between the right posterior cingulate (cue-alpha) and the left fusiform gyri (item-gamma). Gating of memory encoding was dictated by inter-regional negative alpha-gamma coupling. Our graph filtration over MEG network revealed these inter-regional time-delayed cross-frequency connectivity serve gating of memory encoding.
Original languageEnglish
Article number41592
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 7 Feb 2017

Keywords

  • Attention
  • Network topology

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