Abstract
Capsule endoscopy (CE) has proved to be a powerful tool in the diagnosis and management of small bowel disorders since its introduction in 2001. However, white light imaging (WLI) is the principal technology used in clinical CE at present, and therefore, CE is limited to mucosal inspection, with diagnosis remaining reliant on visible manifestations of disease. The introduction of WLI CE has motivated a wide range of research to improve its diagnostic capabilities through integration with other sensing modalities. These developments have the potential to overcome the limitations of WLI through enhanced detection of subtle mucosal microlesions and submucosal and/or transmural pathology, providing novel diagnostic avenues. Other research aims to utilize a range of sensors to measure physiological parameters or to discover new biomarkers to improve the sensitivity, specificity and thus the clinical utility of CE. This multidisciplinary Review summarizes research into non-WLI CE devices by organizing them into a taxonomic structure on the basis of their sensing modality. The potential of these capsules to realize clinically useful virtual biopsy and computer-aided diagnosis (CADx) is also reported.
Original language | English |
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Pages (from-to) | 429–447 |
Number of pages | 19 |
Journal | Nature Reviews Gastroenterology and Hepatology |
Volume | 16 |
Issue number | 7 |
Early online date | 15 Apr 2019 |
DOIs | |
Publication status | Published - Jul 2019 |
Bibliographical note
Funding Information:This work was supported by the UK Engineering and Physical Sciences Research Council under the grant EP/K034537/1, entitled Sonopill, and by the European Commission within the framework of the “Endoscopic versatile robotic guidance, diagnosis and therapy of magnetic-driven soft-tethered endo-luminal robots” Project-H2020-ICT-24-2015 (EU Project-G.A. number: 688592). The authors acknowledge the support of V. Mitrakos in reviewing this manuscript.
Funding Information:
A.K. has received material support for research from SynMedUK and travel support from Aquilant/Jinshan Technology. He was awarded a European Society of Gastrointestinal Endoscopy (ESGE)-Given Imaging grant in 2011 and is a co-founder of AJM Medicaps. J.N.P. sits on the advisory board of Dr Falk and has previously received research support from Fujifilm. S.C., M.P.Y.D., B.F.C. and G.Cu. were all members of the Sonopill project, which was funded by the Engineering and Physical Sciences Research Council. G.Ci. and A.K. are funded by the European Commission under the “Endoscopic versatile robotic guidance, diagnosis and therapy of magnetic-driven soft-tethered endoluminal robots” Project-H2020-ICT-24-2015 (EU Project-G.A. number: 688592).
Publisher Copyright:
© 2019, Springer Nature Limited.
ASJC Scopus subject areas
- Hepatology
- Gastroenterology