TY - JOUR
T1 - Gamma-glutamyltransferase: value of its measurement in paediatrics
AU - Cabrera-Abreu, JC
AU - Green, Anne
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Gamma-glutamyltransferase (GGT) is a microsomal enzyme that is widely distributed in human tissues involved in secretory and absorptive processes, particularly the bile canaliculi. Serum GGT is elevated in liver diseases affecting the biliary system, such as extrahepatic biliary atresia, sclerosing cholangitis and progressive familial intrahepatic cholestasis (PFIC) type 3. Conversely, two other subtypes of PFIC have normal or low serum GGT activity, discordant with the degree of cholestasis. GGT is also useful in detecting cholestasis associated with parenteral nutrition and assessing the efficacy of ursodeoxycholic acid in its treatment. GGT may also help screening for biliary complications on patients that have undergone orthotopic liver transplantation. The reference range for GGT is age dependent. In normal full-term neonates the activity at birth is approximately six to seven times the upper limit of the adult reference range. The activity then declines, reaching adult levels by the age of 5-7 months.
AB - Gamma-glutamyltransferase (GGT) is a microsomal enzyme that is widely distributed in human tissues involved in secretory and absorptive processes, particularly the bile canaliculi. Serum GGT is elevated in liver diseases affecting the biliary system, such as extrahepatic biliary atresia, sclerosing cholangitis and progressive familial intrahepatic cholestasis (PFIC) type 3. Conversely, two other subtypes of PFIC have normal or low serum GGT activity, discordant with the degree of cholestasis. GGT is also useful in detecting cholestasis associated with parenteral nutrition and assessing the efficacy of ursodeoxycholic acid in its treatment. GGT may also help screening for biliary complications on patients that have undergone orthotopic liver transplantation. The reference range for GGT is age dependent. In normal full-term neonates the activity at birth is approximately six to seven times the upper limit of the adult reference range. The activity then declines, reaching adult levels by the age of 5-7 months.
UR - http://www.scopus.com/inward/record.url?scp=0036151587&partnerID=8YFLogxK
U2 - 10.1258/0004563021901685
DO - 10.1258/0004563021901685
M3 - Article
C2 - 11853185
VL - 39
SP - 22
EP - 25
JO - Annals of Clinical Biochemistry
JF - Annals of Clinical Biochemistry
ER -