Further developments towards a genome-scale metabolic model of yeast

Paul D Dobson; Kieran Smallbone; Daniel Jameson; Evangelos Simeonidis; Karin Lanthaler; Pınar Pir; Chuan Lu; Neil Swainston; Warwick B Dunn; Paul Fisher; Duncan Hull; Marie Brown; Olusegun Oshota; Natalie J Stanford; Douglas B Kell; Ross D King; Stephen G Oliver; Robert D Stevens; Pedro Mendes

doi:10.1186/1752-0509-4-145

Further developments towards a genome-scale metabolic model of yeast

Paul D Dobson, Kieran Smallbone, Daniel Jameson, Evangelos Simeonidis, Karin Lanthaler, Pınar Pir, Chuan Lu, Neil Swainston, Warwick B Dunn, Paul Fisher, Duncan Hull, Marie Brown, Olusegun Oshota, Natalie J Stanford, Douglas B Kell, Ross D King, Stephen G Oliver, Robert D Stevens, Pedro Mendes

Biosciences

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity.

Original language	English
Pages (from-to)	145
Journal	BMC systems biology
Volume	4
DOIs	https://doi.org/10.1186/1752-0509-4-145
Publication status	Published - 2010

Access to Document

10.1186/1752-0509-4-145

Cite this

Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., Lu, C., Swainston, N., Dunn, W. B., Fisher, P., Hull, D., Brown, M., Oshota, O., Stanford, N. J., Kell, D. B., King, R. D., Oliver, S. G., Stevens, R. D., & Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC systems biology, 4, 145. https://doi.org/10.1186/1752-0509-4-145

@article{296a81ac58e14360a170f903d6d2514c,

title = "Further developments towards a genome-scale metabolic model of yeast",

abstract = "To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity.",

author = "Dobson, {Paul D} and Kieran Smallbone and Daniel Jameson and Evangelos Simeonidis and Karin Lanthaler and Pınar Pir and Chuan Lu and Neil Swainston and Dunn, {Warwick B} and Paul Fisher and Duncan Hull and Marie Brown and Olusegun Oshota and Stanford, {Natalie J} and Kell, {Douglas B} and King, {Ross D} and Oliver, {Stephen G} and Stevens, {Robert D} and Pedro Mendes",

year = "2010",

doi = "10.1186/1752-0509-4-145",

language = "English",

volume = "4",

pages = "145",

journal = "BMC systems biology",

issn = "1752-0509",

publisher = "Springer",

}

Dobson, PD, Smallbone, K, Jameson, D, Simeonidis, E, Lanthaler, K, Pir, P, Lu, C, Swainston, N, Dunn, WB, Fisher, P, Hull, D, Brown, M, Oshota, O, Stanford, NJ, Kell, DB, King, RD, Oliver, SG, Stevens, RD & Mendes, P 2010, 'Further developments towards a genome-scale metabolic model of yeast', BMC systems biology, vol. 4, pp. 145. https://doi.org/10.1186/1752-0509-4-145

TY - JOUR

T1 - Further developments towards a genome-scale metabolic model of yeast

AU - Dobson, Paul D

AU - Smallbone, Kieran

AU - Jameson, Daniel

AU - Simeonidis, Evangelos

AU - Lanthaler, Karin

AU - Pir, Pınar

AU - Lu, Chuan

AU - Swainston, Neil

AU - Dunn, Warwick B

AU - Fisher, Paul

AU - Hull, Duncan

AU - Brown, Marie

AU - Oshota, Olusegun

AU - Stanford, Natalie J

AU - Kell, Douglas B

AU - King, Ross D

AU - Oliver, Stephen G

AU - Stevens, Robert D

AU - Mendes, Pedro

PY - 2010

Y1 - 2010

N2 - To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity.

AB - To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity.

U2 - 10.1186/1752-0509-4-145

DO - 10.1186/1752-0509-4-145

M3 - Article

C2 - 21029416

SN - 1752-0509

VL - 4

SP - 145

JO - BMC systems biology

JF - BMC systems biology

ER -

Further developments towards a genome-scale metabolic model of yeast

Abstract

Access to Document

Fingerprint

Cite this