Fungal Pathogens: Survival and Replication within Macrophages

Andrew S Gilbert, Robert T Wheeler, Robin C May

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The innate immune system is a critical line of defense against pathogenic fungi. Macrophages act at an early stage of infection, detecting and phagocytizing infectious propagules. To avoid killing at this stage, fungal pathogens use diverse strategies ranging from evasion of uptake to intracellular parasitism. This article will discuss five of the most important human fungal pathogens (Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Coccidiodes immitis, and Histoplasma capsulatum) and consider the strategies and virulence factors adopted by each to survive and replicate within macrophages.

Original languageEnglish
JournalCold Spring Harbor Perspectives in Medicine
DOIs
Publication statusPublished - 10 Nov 2014

Bibliographical note

Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

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