Fungal Interactions with the Human Host: Exploring the Spectrum of Symbiosis

Rebecca Hall, Mairi Noverr

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)
782 Downloads (Pure)

Abstract

Fungi are ubiquitous transient or persistent human colonisers, and form the mycobiome with shifts in niche specific mycobiomes (dysbiosis) being associated with various diseases. These complex interactions of fungal species with the human host can be viewed as a spectrum of symbiotic relationships (i.e. commensal, parasitic, mutualistic, amensalistic). The host relevant outcome of the relationship is the damage to benefit ratio, elegantly described in the damage response framework. This review focuses on Candida albicans, which is the most well studied human fungal symbiont clinically and experimentally, its transition from commensalism to parasitism within the human host, and the factors that influence this relationship.
Original languageEnglish
Pages (from-to)58-64
JournalCurrent Opinion in Microbiology
Volume40
Early online date11 Nov 2017
DOIs
Publication statusPublished - Dec 2017

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