Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: a systematic review and meta-analysis

Henrique Lapo; Amanda Veiga Sardeli; Lilian O. Mariano; Fiona Howroyd; Paulo Roberto Sokoll; Elizabeth Sapey; Mara Patrícia Traina  Chacon-Mikahil

doi:10.1016/j.exger.2024.112617

Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: a systematic review and meta-analysis

Henrique Lapo, Amanda Veiga Sardeli^*, Lilian O. Mariano, Fiona Howroyd, Paulo Roberto Sokoll, Elizabeth Sapey, Mara Patrícia Traina Chacon-Mikahil

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Review article › peer-review

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Abstract

Introduction: Older adults are more likely to acquire the severe manifestation of COVID-19 and the hospitalised survivors experience significant functionality loss. Thus, we aimed to identify the level of functionality in older adults hospitalised due to COVID-19, and the effect of inpatient rehabilitation upon functional recovery.

Methods: A search was performed on July 2024, across five databases to retrieve studies assessing functionality in patients during COVID-19 hospitalisation, with or without rehabilitation.

Results: At admission, higher functionality was significantly higher for survivors than non survivors (standardized mean difference (SMD): 0.83 [0.56; 1.09]). The effect of inpatient rehabilitation on functionality was tested among 38 arms across studies. Inpatient rehabilitation improved functionality SMD across all indexes (1.47 [1.18; 1.77], P ≤ 0.001), with greatest effect in the patients >70 years (2.84 [1.74, 3.93], P = 0.006), compared to their counterparts.

Conclusion: Hospitalisation due to COVID-19 reduced functionality to a higher extent in older adults above 70 years. Inpatient rehabilitation was effective to improve functionality in both age groups.

Protocol registration: PROSPERO CRD42021278619.

Original language	English
Article number	112617
Number of pages	12
Journal	Experimental gerontology
Volume	198
Early online date	5 Nov 2024
DOIs	https://doi.org/10.1016/j.exger.2024.112617
Publication status	Published - Dec 2024

Keywords

Activities of daily living
Functional status
Independence
Physiotherapy
Aging
SARS-CoV-2

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@article{754b8bf7b7224f96a292093d943cfe5d,

title = "Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: a systematic review and meta-analysis",

abstract = "Introduction: Older adults are more likely to acquire the severe manifestation of COVID-19 and the hospitalised survivors experience significant functionality loss. Thus, we aimed to identify the level of functionality in older adults hospitalised due to COVID-19, and the effect of inpatient rehabilitation upon functional recovery.Methods: A search was performed on July 2024, across five databases to retrieve studies assessing functionality in patients during COVID-19 hospitalisation, with or without rehabilitation.Results: At admission, higher functionality was significantly higher for survivors than non survivors (standardized mean difference (SMD): 0.83 [0.56; 1.09]). The effect of inpatient rehabilitation on functionality was tested among 38 arms across studies. Inpatient rehabilitation improved functionality SMD across all indexes (1.47 [1.18; 1.77], P ≤ 0.001), with greatest effect in the patients >70 years (2.84 [1.74, 3.93], P = 0.006), compared to their counterparts.Conclusion: Hospitalisation due to COVID-19 reduced functionality to a higher extent in older adults above 70 years. Inpatient rehabilitation was effective to improve functionality in both age groups.Protocol registration: PROSPERO CRD42021278619.",

keywords = "Activities of daily living, Functional status, Independence, Physiotherapy, Aging, SARS-CoV-2",

author = "Henrique Lapo and {Veiga Sardeli}, Amanda and Mariano, {Lilian O.} and Fiona Howroyd and Sokoll, {Paulo Roberto} and Elizabeth Sapey and Chacon-Mikahil, {Mara Patr{\'i}cia Traina}",

year = "2024",

month = dec,

doi = "10.1016/j.exger.2024.112617",

language = "English",

volume = "198",

journal = "Experimental gerontology",

issn = "0531-5565",

publisher = "Elsevier",

}

TY - JOUR

T1 - Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation

T2 - a systematic review and meta-analysis

AU - Lapo, Henrique

AU - Veiga Sardeli, Amanda

AU - Mariano, Lilian O.

AU - Howroyd, Fiona

AU - Sokoll, Paulo Roberto

AU - Sapey, Elizabeth

AU - Chacon-Mikahil, Mara Patrícia Traina

PY - 2024/12

Y1 - 2024/12

N2 - Introduction: Older adults are more likely to acquire the severe manifestation of COVID-19 and the hospitalised survivors experience significant functionality loss. Thus, we aimed to identify the level of functionality in older adults hospitalised due to COVID-19, and the effect of inpatient rehabilitation upon functional recovery.Methods: A search was performed on July 2024, across five databases to retrieve studies assessing functionality in patients during COVID-19 hospitalisation, with or without rehabilitation.Results: At admission, higher functionality was significantly higher for survivors than non survivors (standardized mean difference (SMD): 0.83 [0.56; 1.09]). The effect of inpatient rehabilitation on functionality was tested among 38 arms across studies. Inpatient rehabilitation improved functionality SMD across all indexes (1.47 [1.18; 1.77], P ≤ 0.001), with greatest effect in the patients >70 years (2.84 [1.74, 3.93], P = 0.006), compared to their counterparts.Conclusion: Hospitalisation due to COVID-19 reduced functionality to a higher extent in older adults above 70 years. Inpatient rehabilitation was effective to improve functionality in both age groups.Protocol registration: PROSPERO CRD42021278619.

AB - Introduction: Older adults are more likely to acquire the severe manifestation of COVID-19 and the hospitalised survivors experience significant functionality loss. Thus, we aimed to identify the level of functionality in older adults hospitalised due to COVID-19, and the effect of inpatient rehabilitation upon functional recovery.Methods: A search was performed on July 2024, across five databases to retrieve studies assessing functionality in patients during COVID-19 hospitalisation, with or without rehabilitation.Results: At admission, higher functionality was significantly higher for survivors than non survivors (standardized mean difference (SMD): 0.83 [0.56; 1.09]). The effect of inpatient rehabilitation on functionality was tested among 38 arms across studies. Inpatient rehabilitation improved functionality SMD across all indexes (1.47 [1.18; 1.77], P ≤ 0.001), with greatest effect in the patients >70 years (2.84 [1.74, 3.93], P = 0.006), compared to their counterparts.Conclusion: Hospitalisation due to COVID-19 reduced functionality to a higher extent in older adults above 70 years. Inpatient rehabilitation was effective to improve functionality in both age groups.Protocol registration: PROSPERO CRD42021278619.

KW - Activities of daily living

KW - Functional status

KW - Independence

KW - Physiotherapy

KW - Aging

KW - SARS-CoV-2

U2 - 10.1016/j.exger.2024.112617

DO - 10.1016/j.exger.2024.112617

M3 - Review article

SN - 0531-5565

VL - 198

JO - Experimental gerontology

JF - Experimental gerontology

M1 - 112617

ER -

Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: a systematic review and meta-analysis

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Keywords

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