Functional significance of the platelet immune receptors GPVI and CLEC-2

Julie Rayes, Steve P. Watson, Bernhard Nieswandt

Research output: Contribution to journalReview articlepeer-review

90 Citations (Scopus)
2 Downloads (Pure)

Abstract

Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. CLEC-2 is activated by the transmembrane protein podoplanin, which is found outside of the vasculature and is upregulated in development, inflammation, and cancer, but there is also evidence for additional ligands. In this Review, we discuss the physiological and pathological roles of CLEC-2 and GPVI and their potential as targets in thrombosis and thromboinflammatory disorders (i.e., disorders in which inflammation plays a critical role in the ensuing thrombosis) relative to current antiplatelet drugs.

Original languageEnglish
Article numberCI122955
Pages (from-to)12-23
JournalJournal of Clinical Investigation
Volume129
Issue number1
DOIs
Publication statusPublished - 2 Jan 2019

ASJC Scopus subject areas

  • Medicine(all)

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