From start to finish: amino-terminal protein modifications as degradation signals in plants

Daniel J Gibbs, Mark Bailey, Hannah M Tedds, Michael J Holdsworth

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38 Citations (Scopus)
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Abstract

The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- andposttranslational modifications. Many of these create degradation signals (N-degrons) thatmediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. Inplants, the N-end rule pathway has emerged as a major system for regulated control of proteinstability. Nt-arginylation-dependent degradation regulates multiple growth, development andstress responses, and recently identified functions of Nt-acetylation can also be linked to effectson the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recentadvances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants.
Original languageEnglish
Pages (from-to)1188-1194
JournalNew Phytologist
Volume211
Issue number4
Early online date21 Jul 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • N-degron
  • N-end rule
  • Nt-acetylation
  • N-terminus
  • protease
  • protein modification
  • proteolysis
  • ubiquitinproteasome system

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