Abstract
The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- andposttranslational modifications. Many of these create degradation signals (N-degrons) thatmediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. Inplants, the N-end rule pathway has emerged as a major system for regulated control of proteinstability. Nt-arginylation-dependent degradation regulates multiple growth, development andstress responses, and recently identified functions of Nt-acetylation can also be linked to effectson the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recentadvances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants.
Original language | English |
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Pages (from-to) | 1188-1194 |
Journal | New Phytologist |
Volume | 211 |
Issue number | 4 |
Early online date | 21 Jul 2016 |
DOIs | |
Publication status | Published - Sept 2016 |
Keywords
- N-degron
- N-end rule
- Nt-acetylation
- N-terminus
- protease
- protein modification
- proteolysis
- ubiquitinproteasome system