FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis

Amr M El Zawily, Markus Schwarzländer, Iris Finkemeier, Iain G Johnston, Abdelilah Benamar, Yongguo Cao, Clémence Gissot, Andreas J Meyer, Ken Wilson, Raju Datla, David Macherel, Nick S Jones, David C Logan

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically, and dynamically from those in other eukaryotes. FRIENDLY, a member of the CLUSTERED MITOCHONDRIA superfamily, is conserved among eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY function in Arabidopsis (Arabidopsis thaliana) leads to mitochondrial clustering and the effects of this aberrant chondriome on cell and whole-plant physiology. We present evidence for a role of FRIENDLY in mediating intermitochondrial association, which is a necessary prelude to mitochondrial fusion. We demonstrate that disruption of mitochondrial association, motility, and chondriome structure in friendly affects mitochondrial quality control and leads to mitochondrial stress, cell death, and strong growth phenotypes.

Original languageEnglish
Pages (from-to)808-828
Number of pages21
JournalPlant Physiology
Early online date27 Aug 2014
Publication statusPublished - Oct 2014


  • Actins
  • Arabidopsis
  • Arabidopsis Proteins
  • Cytoskeleton
  • Membrane Potential, Mitochondrial
  • Mitochondria
  • Photosynthesis
  • Transcriptome


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