Fractures and Fanconi syndrome due to prolonged sodium valproate use

N Dhillon, Wolfgang Högler

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


BACKGROUND: Sodium valproate (VPA) is commonly used to treat epilepsy in children. Renal dysfunction is a rare side eff ect but can present as tubulopathy such as Fanconi syndrome.

CASE REPORT: We report on an 8-year-old disabled girl with myoclonic epilepsy who was referred for investigation of recurrent low impact fractures of the distal femur which were initially thought to be caused by her severe immobility. However, she was subsequently found to have hypophosphataemia secondary to Fanconi syndrome due to prolonged VPA use. After VPA withdrawal renal function and serum phosphate levels normalised and X-rays improved dramatically.

CONCLUSION: The possibility of drug-induced osteoporosis and fractures should always be considered in disabled children, even in the presence of severe immobility.

Original languageEnglish
Pages (from-to)119-21
Number of pages3
Issue number3
Publication statusPublished - Jun 2011


  • Child
  • Disabled Children
  • Epilepsies, Myoclonic
  • Fanconi Syndrome
  • Female
  • Femoral Fractures
  • Humans
  • Valproic Acid
  • Case Reports
  • Journal Article


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