Folate Improves Endothelial Function in Coronary Artery Disease.  An Effect Mediated by Reduction of Intracellular Superoxide?

Sagar Doshi; IFW McDowell; SJ Moat; D Lang; RG Newcombe; MB Kredan; MJ Lewis; J Goodfellow

doi:10.1161/hq0701.092000

Folate Improves Endothelial Function in Coronary Artery Disease. An Effect Mediated by Reduction of Intracellular Superoxide?

Sagar Doshi, IFW McDowell, SJ Moat, D Lang, RG Newcombe, MB Kredan, MJ Lewis, J Goodfellow

Birmingham Medical School

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234 Citations (Scopus)

Abstract

Homocysteine is a risk factor for coronary artery disease (CAD). Folic acid lowers homocysteine and may improve endothelial function in CAD, although the mechanism is unclear. We investigated the effect of folic acid on endothelial function, homocysteine, and oxidative stress in patients with CAD. We also examined the acute effect of 5-methyltetrahydrofolate (5-MTHF), the principal circulating folate, on endothelial function in vivo and on intracellular superoxide in cultured endothelial cells. A randomized crossover study of folic acid (5 mg daily) for 6 weeks was undertaken in 52 patients with CAD. Ten further patients were given intra-arterial 5-MTHF. Endothelial function was assessed by flow-mediated dilatation (FMD). Folic acid increased plasma folate (P

Original language	English
Pages (from-to)	1196-202
Number of pages	7
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	21
Issue number	7
DOIs	https://doi.org/10.1161/hq0701.092000
Publication status	Published - 1 Jul 2001

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title = "Folate Improves Endothelial Function in Coronary Artery Disease. An Effect Mediated by Reduction of Intracellular Superoxide?",

abstract = "Homocysteine is a risk factor for coronary artery disease (CAD). Folic acid lowers homocysteine and may improve endothelial function in CAD, although the mechanism is unclear. We investigated the effect of folic acid on endothelial function, homocysteine, and oxidative stress in patients with CAD. We also examined the acute effect of 5-methyltetrahydrofolate (5-MTHF), the principal circulating folate, on endothelial function in vivo and on intracellular superoxide in cultured endothelial cells. A randomized crossover study of folic acid (5 mg daily) for 6 weeks was undertaken in 52 patients with CAD. Ten further patients were given intra-arterial 5-MTHF. Endothelial function was assessed by flow-mediated dilatation (FMD). Folic acid increased plasma folate (P",

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T1 - Folate Improves Endothelial Function in Coronary Artery Disease. An Effect Mediated by Reduction of Intracellular Superoxide?

AU - Doshi, Sagar

AU - McDowell, IFW

AU - Moat, SJ

AU - Lang, D

AU - Newcombe, RG

AU - Kredan, MB

AU - Lewis, MJ

AU - Goodfellow, J

PY - 2001/7/1

Y1 - 2001/7/1

N2 - Homocysteine is a risk factor for coronary artery disease (CAD). Folic acid lowers homocysteine and may improve endothelial function in CAD, although the mechanism is unclear. We investigated the effect of folic acid on endothelial function, homocysteine, and oxidative stress in patients with CAD. We also examined the acute effect of 5-methyltetrahydrofolate (5-MTHF), the principal circulating folate, on endothelial function in vivo and on intracellular superoxide in cultured endothelial cells. A randomized crossover study of folic acid (5 mg daily) for 6 weeks was undertaken in 52 patients with CAD. Ten further patients were given intra-arterial 5-MTHF. Endothelial function was assessed by flow-mediated dilatation (FMD). Folic acid increased plasma folate (P

AB - Homocysteine is a risk factor for coronary artery disease (CAD). Folic acid lowers homocysteine and may improve endothelial function in CAD, although the mechanism is unclear. We investigated the effect of folic acid on endothelial function, homocysteine, and oxidative stress in patients with CAD. We also examined the acute effect of 5-methyltetrahydrofolate (5-MTHF), the principal circulating folate, on endothelial function in vivo and on intracellular superoxide in cultured endothelial cells. A randomized crossover study of folic acid (5 mg daily) for 6 weeks was undertaken in 52 patients with CAD. Ten further patients were given intra-arterial 5-MTHF. Endothelial function was assessed by flow-mediated dilatation (FMD). Folic acid increased plasma folate (P

U2 - 10.1161/hq0701.092000

DO - 10.1161/hq0701.092000

M3 - Article

C2 - 11451751

SN - 1524-4636

VL - 21

SP - 1196

EP - 1202

JO - Arteriosclerosis Thrombosis and Vascular Biology

JF - Arteriosclerosis Thrombosis and Vascular Biology

IS - 7

ER -

Folate Improves Endothelial Function in Coronary Artery Disease. An Effect Mediated by Reduction of Intracellular Superoxide?

Abstract

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