Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success

Liam S Redgrave; Sam B Sutton; Mark A Webber; Laura J V Piddock

doi:10.1016/j.tim.2014.04.007

Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success

Liam S Redgrave, Sam B Sutton, Mark A Webber, Laura J V Piddock

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396 Citations (Scopus)

Abstract

Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.

Original language	English
Pages (from-to)	438-45
Number of pages	8
Journal	Trends in Microbiology
Volume	22
Issue number	8
Early online date	16 May 2014
DOIs	https://doi.org/10.1016/j.tim.2014.04.007
Publication status	Published - 1 Aug 2014

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10.1016/j.tim.2014.04.007

Evolution of Multidrug Resistance in Salmonella Enterica Serovar Typhimurium as a Result of Biocide Exposure
Webber, M., Pallen, M. & Piddock, L.
Biotechnology & Biological Sciences Research Council
13/07/09 → 12/07/12
Project: Research Councils
Unravelling Multiple Antibiotic Resistance in Salmonella Enterica
Piddock, L.
Medical Research Council
1/04/06 → 31/03/09
Project: Research Councils

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title = "Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success",

abstract = "Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.",

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AU - Redgrave, Liam S

AU - Sutton, Sam B

AU - Webber, Mark A

AU - Piddock, Laura J V

PY - 2014/8/1

Y1 - 2014/8/1

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Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success

Abstract

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Projects

Evolution of Multidrug Resistance in Salmonella Enterica Serovar Typhimurium as a Result of Biocide Exposure

Unravelling Multiple Antibiotic Resistance in Salmonella Enterica

Cite this