TY - JOUR
T1 - Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
AU - Buckley, Christopher
AU - Pilling, Darrell
AU - Lord, Janet
AU - Akbar, AN
AU - Scheel-Toellner, Dagmar
AU - Salmon, Michael
PY - 2001/4/1
Y1 - 2001/4/1
N2 - Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.
AB - Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.
UR - http://www.scopus.com/inward/record.url?scp=0034923219&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(01)01863-4
DO - 10.1016/S1471-4906(01)01863-4
M3 - Article
C2 - 11274925
SN - 1471-4981
VL - 22
SP - 199
EP - 204
JO - Trends in Immunology
JF - Trends in Immunology
IS - 4
ER -