Fibroblast heterogeneity in 2025

Adam P. Croft; Annie Hackland

doi:10.1038/s41584-025-01345-3

Fibroblast heterogeneity in 2025

Adam P. Croft^*
, Annie Hackland

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Review article

Abstract

Advances in cellular and spatial profiling technologies have rapidly expanded the understanding of fibroblast heterogeneity within the target tissues of disease. In 2025, there has been a shift towards a consensus definition of shared cross-tissue fibroblast states and a greater understanding of their molecular drivers and disease-relevant effector functions.

Original language	English
Number of pages	3
Journal	Nature Reviews Rheumatology
DOIs	https://doi.org/10.1038/s41584-025-01345-3
Publication status	E-pub ahead of print - 19 Dec 2025

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title = "Fibroblast heterogeneity in 2025",

abstract = "Advances in cellular and spatial profiling technologies have rapidly expanded the understanding of fibroblast heterogeneity within the target tissues of disease. In 2025, there has been a shift towards a consensus definition of shared cross-tissue fibroblast states and a greater understanding of their molecular drivers and disease-relevant effector functions.",

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M3 - Review article

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JO - Nature Reviews Rheumatology

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Fibroblast heterogeneity in 2025

Abstract

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