FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Susanna Søberg; Camilla H. Sandholt; Naja Z. Jespersen; Ulla Toft; Anja L. Madsen; Stephanie von Holstein-Rathlou; Trisha J. Grevengoed; Karl B. Christensen; Wender L. P. Bredie; Matthew J. Potthoff; Thomas P J Solomon; Camilla Scheele; Allan Linneberg; Torben Jørgensen; Oluf Pedersen; Torben Hansen; Matthew P. Gillum; Niels Grarup

doi:10.1016/j.cmet.2017.04.009

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Susanna Søberg, Camilla H. Sandholt, Naja Z. Jespersen, Ulla Toft, Anja L. Madsen, Stephanie von Holstein-Rathlou, Trisha J. Grevengoed, Karl B. Christensen, Wender L. P. Bredie, Matthew J. Potthoff, Thomas P J Solomon, Camilla Scheele, Allan Linneberg, Torben Jørgensen, Oluf Pedersen, Torben Hansen, Matthew P. Gillum, Niels Grarup

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.

Original language	English
Pages (from-to)	1045-1053.e6
Journal	Cell Metabolism
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2017.04.009
Publication status	Published - 2 May 2017

Keywords

Journal Article
fibroblast growth factor 21
FGF21
macronutrient preference
sucrose preference
food preference
genetic association study
human
sugar appetitie
reward seeking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cmet.2017.04.009Licence: None: All rights reserved

http://www.sciencedirect.com/science/article/pii/S1550413117302140Licence: None: All rights reserved

Cite this

Søberg, S., Sandholt, C. H., Jespersen, N. Z., Toft, U., Madsen, A. L., von Holstein-Rathlou, S., Grevengoed, T. J., Christensen, K. B., Bredie, W. L. P., Potthoff, M. J., Solomon, T. P. J., Scheele, C., Linneberg, A., Jørgensen, T., Pedersen, O., Hansen, T., Gillum, M. P., & Grarup, N. (2017). FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. Cell Metabolism, 25(5), 1045-1053.e6. https://doi.org/10.1016/j.cmet.2017.04.009

@article{d8309312dd2d431b8c640351dfe17e13,

title = "FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans",

abstract = "The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.",

keywords = "Journal Article, fibroblast growth factor 21, FGF21, macronutrient preference , sucrose preference , food preference , genetic association study , human , sugar appetitie , reward seeking",

author = "Susanna S{\o}berg and Sandholt, {Camilla H.} and Jespersen, {Naja Z.} and Ulla Toft and Madsen, {Anja L.} and {von Holstein-Rathlou}, Stephanie and Grevengoed, {Trisha J.} and Christensen, {Karl B.} and Bredie, {Wender L. P.} and Potthoff, {Matthew J.} and Solomon, {Thomas P J} and Camilla Scheele and Allan Linneberg and Torben J{\o}rgensen and Oluf Pedersen and Torben Hansen and Gillum, {Matthew P.} and Niels Grarup",

year = "2017",

month = may,

day = "2",

doi = "10.1016/j.cmet.2017.04.009",

language = "English",

volume = "25",

pages = "1045--1053.e6",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Elsevier",

number = "5",

}

Søberg, S, Sandholt, CH, Jespersen, NZ, Toft, U, Madsen, AL, von Holstein-Rathlou, S, Grevengoed, TJ, Christensen, KB, Bredie, WLP, Potthoff, MJ, Solomon, TPJ, Scheele, C, Linneberg, A, Jørgensen, T, Pedersen, O, Hansen, T, Gillum, MP & Grarup, N 2017, 'FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans', Cell Metabolism, vol. 25, no. 5, pp. 1045-1053.e6. https://doi.org/10.1016/j.cmet.2017.04.009

TY - JOUR

T1 - FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

AU - Søberg, Susanna

AU - Sandholt, Camilla H.

AU - Jespersen, Naja Z.

AU - Toft, Ulla

AU - Madsen, Anja L.

AU - von Holstein-Rathlou, Stephanie

AU - Grevengoed, Trisha J.

AU - Christensen, Karl B.

AU - Bredie, Wender L. P.

AU - Potthoff, Matthew J.

AU - Solomon, Thomas P J

AU - Scheele, Camilla

AU - Linneberg, Allan

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Gillum, Matthew P.

AU - Grarup, Niels

PY - 2017/5/2

Y1 - 2017/5/2

N2 - The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.

AB - The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors. This revealed statistically significant associations between FGF21 rs838133 and increased consumption of candy, as well as nominal associations with increased alcohol intake and daily smoking. Moreover, in a separate clinical study, plasma FGF21 levels increased acutely after oral sucrose ingestion and were elevated in fasted sweet-disliking individuals. These data suggest the liver may secrete hormones that influence eating behavior.

KW - Journal Article

KW - fibroblast growth factor 21

KW - FGF21

KW - macronutrient preference

KW - sucrose preference

KW - food preference

KW - genetic association study

KW - human

KW - sugar appetitie

KW - reward seeking

U2 - 10.1016/j.cmet.2017.04.009

DO - 10.1016/j.cmet.2017.04.009

M3 - Article

C2 - 28467924

SN - 1550-4131

VL - 25

SP - 1045-1053.e6

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this