Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial

FOxTROT Collaborative Group, Elizabeth Magill, Kelly Handley

Research output: Contribution to journalArticlepeer-review

240 Citations (Scopus)

Abstract

Preoperative (neoadjuvant) chemotherapy and radiotherapy are more effective than similar postoperative treatment for oesophageal, gastric, and rectal cancers, perhaps because of more effective micrometastasis eradication and reduced risk of incomplete excision and tumour cell shedding during surgery. The FOxTROT trial aims to investigate the feasibility, safety, and efficacy of preoperative chemotherapy for colon cancer.
Original languageEnglish
Pages (from-to)1152-60
Number of pages9
JournalThe Lancet Oncology
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2012

Bibliographical note

Copyright © 2012 Elsevier Ltd. All rights reserved.

Keywords

  • Neoplasm Staging
  • Rectal Neoplasms
  • Combined Modality Therapy
  • Humans
  • Neoadjuvant Therapy
  • Aged
  • Antibodies, Monoclonal
  • Aged, 80 and over
  • Fluorouracil
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols
  • Organoplatinum Compounds
  • Middle Aged
  • Preoperative Period
  • Colonic Neoplasms
  • Female
  • Male

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