TY - JOUR
T1 - Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue
AU - Batchelor, H.K.
AU - Tang, M.
AU - Dettmar, P.W.
AU - Hampson, F.C.
AU - Jolliffe, I.G.
AU - Craig, D.Q.M.
PY - 2004/3/1
Y1 - 2004/3/1
N2 - This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).
AB - This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-1442335225&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2003.10.007
DO - 10.1016/j.ejpb.2003.10.007
M3 - Article
AN - SCOPUS:1442335225
SN - 0939-6411
VL - 57
SP - 295
EP - 298
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
IS - 2
ER -
