TY - GEN
T1 - Faster tissue interface analysis from raman microscopy images using compressed factorisation
AU - Palmer, Andrew D.
AU - Bannerman, Alistair
AU - Grover, Liam
AU - Styles, Iain B.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The structure of an artificial ligament was examined using Raman microscopy in combination with novel data analysis. Basis approximation and compressed principal component analysis are shown to provide efficient compression of confocal Raman microscopy images, alongside powerful methods for unsupervised analysis. This scheme allows the acceleration of data mining, such as principal component analysis, as they can be performed on the compressed data representation, providing a decrease in the factorisation time of a single image from five minutes to under a second. Using this workflow the interface region between a chemically engineered ligament construct and a bone-mimic anchor was examined. Natural ligament contains a striated interface between the bone and tissue that provides improved mechanical load tolerance, a similar interface was found in the ligament construct.
AB - The structure of an artificial ligament was examined using Raman microscopy in combination with novel data analysis. Basis approximation and compressed principal component analysis are shown to provide efficient compression of confocal Raman microscopy images, alongside powerful methods for unsupervised analysis. This scheme allows the acceleration of data mining, such as principal component analysis, as they can be performed on the compressed data representation, providing a decrease in the factorisation time of a single image from five minutes to under a second. Using this workflow the interface region between a chemically engineered ligament construct and a bone-mimic anchor was examined. Natural ligament contains a striated interface between the bone and tissue that provides improved mechanical load tolerance, a similar interface was found in the ligament construct.
UR - http://www.scopus.com/inward/record.url?scp=84899719284&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84899719284
SN - 9780819496461
T3 - Optics InfoBase Conference Papers
BT - European Conference on Biomedical Optics, ECBO 2013
PB - Optical Society of America
T2 - European Conference on Biomedical Optics, ECBO 2013
Y2 - 12 May 2013 through 16 May 2013
ER -