Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

P Sklar; SB Gabriel; MG McInnis; P Bennett; YM Lim; G Tsan; S Schaffner; G Kirov; Ian Jones; M Owen; Nicholas Craddock; JR DePaulo; ES Lander

doi:10.1038/sj.mp.4001058

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

P Sklar, SB Gabriel, MG McInnis, P Bennett, YM Lim, G Tsan, S Schaffner, G Kirov, Ian Jones, M Owen, Nicholas Craddock, JR DePaulo, ES Lander

Birmingham Medical School

Research output: Contribution to journal › Article

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Abstract

Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and bipolar disorder was tested by genotyping 90 single-nucleotide polymorphisms (SNPs) in these genes in 136 parent-proband trios. In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P

Original language	English
Pages (from-to)	579-593
Number of pages	15
Journal	Molecular Psychiatry
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/sj.mp.4001058
Publication status	Published - 1 Jan 2002

Keywords

genomic
susceptibility loci
SNP
single-nucleotide polymorphism
linkage
transmission disequilibrium test

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10.1038/sj.mp.4001058

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abstract = "Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and bipolar disorder was tested by genotyping 90 single-nucleotide polymorphisms (SNPs) in these genes in 136 parent-proband trios. In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P",

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AU - Sklar, P

AU - Gabriel, SB

AU - McInnis, MG

AU - Bennett, P

AU - Lim, YM

AU - Tsan, G

AU - Schaffner, S

AU - Kirov, G

AU - Jones, Ian

AU - Owen, M

AU - Craddock, Nicholas

AU - DePaulo, JR

AU - Lander, ES

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and bipolar disorder was tested by genotyping 90 single-nucleotide polymorphisms (SNPs) in these genes in 136 parent-proband trios. In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P

AB - Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and bipolar disorder was tested by genotyping 90 single-nucleotide polymorphisms (SNPs) in these genes in 136 parent-proband trios. In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P

KW - genomic

KW - susceptibility loci

KW - SNP

KW - single-nucleotide polymorphism

KW - linkage

KW - transmission disequilibrium test

U2 - 10.1038/sj.mp.4001058

DO - 10.1038/sj.mp.4001058

M3 - Article

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JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 6

ER -

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

Abstract

Keywords

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