Familial hepatoblastoma and APC gene mutuations: renewed call for mol. research

Jeremy Pritchard, Richard Grundy, Jean de Ville de Goyet, D Thomas, R Davidson, Patrick McKiernan

Research output: Contribution to journalArticle

37 Citations (Scopus)


Recent findings have increased our understanding of the molecular mechanisms involved in the pathogenesis of hepatoblastoma and their relationship to the molecular pathology of familial adenomatous polyposis (FAP). Here, we describe hepatoblastoma in siblings who share a gene mutation for FAP inherited from their father. This observation confirms the link between these diseases and has implications for future molecular research. We also raise the question; should other members of 'at-risk' families be screened following a new diagnosis of either hepatoblastoma or FAP? (C) 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2200-2204
Number of pages5
JournalEuropean Journal of Cancer
Publication statusPublished - 1 Jan 2003


  • family screening
  • familial adenomatous polyposis
  • APC gene mutation
  • hepatoblastoma and adenomatous polyposis coli gene
  • hepatoblastoma


Dive into the research topics of 'Familial hepatoblastoma and APC gene mutuations: renewed call for mol. research'. Together they form a unique fingerprint.

Cite this