TY - JOUR
T1 - Familial hepatoblastoma and APC gene mutuations: renewed call for mol. research
AU - Pritchard, Jeremy
AU - Grundy, Richard
AU - de Ville de Goyet, Jean
AU - Thomas, D
AU - Davidson, R
AU - McKiernan, Patrick
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Recent findings have increased our understanding of the molecular mechanisms involved in the pathogenesis of hepatoblastoma and their relationship to the molecular pathology of familial adenomatous polyposis (FAP). Here, we describe hepatoblastoma in siblings who share a gene mutation for FAP inherited from their father. This observation confirms the link between these diseases and has implications for future molecular research. We also raise the question; should other members of 'at-risk' families be screened following a new diagnosis of either hepatoblastoma or FAP? (C) 2003 Elsevier Ltd. All rights reserved.
AB - Recent findings have increased our understanding of the molecular mechanisms involved in the pathogenesis of hepatoblastoma and their relationship to the molecular pathology of familial adenomatous polyposis (FAP). Here, we describe hepatoblastoma in siblings who share a gene mutation for FAP inherited from their father. This observation confirms the link between these diseases and has implications for future molecular research. We also raise the question; should other members of 'at-risk' families be screened following a new diagnosis of either hepatoblastoma or FAP? (C) 2003 Elsevier Ltd. All rights reserved.
KW - family screening
KW - familial adenomatous polyposis
KW - APC gene mutation
KW - hepatoblastoma and adenomatous polyposis coli gene
KW - hepatoblastoma
UR - http://www.scopus.com/inward/record.url?scp=0142091577&partnerID=8YFLogxK
U2 - 10.1016/S0959-8049(03)00618-X
DO - 10.1016/S0959-8049(03)00618-X
M3 - Article
C2 - 14522379
SN - 1879-0852
SN - 1879-2995
VL - 39
SP - 2200
EP - 2204
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -