Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(Ethylene Glycol) acrylate-based system

S.J. Leigh; H.T.J. Gilbert; I.A. Barker; J.M. Becker; S.M. Richardson; J.A. Hoyland; J.A. Covington; A.P. Dove

doi:10.1021/bm3015736

Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(Ethylene Glycol) acrylate-based system

S.J. Leigh
, H.T.J. Gilbert
, I.A. Barker
, J.M. Becker
, S.M. Richardson
, J.A. Hoyland
, J.A. Covington
, A.P. Dove

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.

Original language	English
Pages (from-to)	186–192
Journal	Biomacromolecules
Volume	14
Issue number	1
DOIs	https://doi.org/10.1021/bm3015736
Publication status	Published - 20 Nov 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

microstereolithography
3D scaffolds

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10.1021/bm3015736

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abstract = "A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.",

keywords = "microstereolithography, 3D scaffolds",

author = "S.J. Leigh and H.T.J. Gilbert and I.A. Barker and J.M. Becker and S.M. Richardson and J.A. Hoyland and J.A. Covington and A.P. Dove",

year = "2012",

month = nov,

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doi = "10.1021/bm3015736",

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T1 - Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(Ethylene Glycol) acrylate-based system

AU - Leigh, S.J.

AU - Gilbert, H.T.J.

AU - Barker, I.A.

AU - Becker, J.M.

AU - Richardson, S.M.

AU - Hoyland, J.A.

AU - Covington, J.A.

AU - Dove, A.P.

PY - 2012/11/20

Y1 - 2012/11/20

N2 - A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.

AB - A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.

KW - microstereolithography

KW - 3D scaffolds

UR - https://www.scopus.com/pages/publications/84872563862

U2 - 10.1021/bm3015736

DO - 10.1021/bm3015736

M3 - Article

SN - 1525-7797

VL - 14

SP - 186

EP - 192

JO - Biomacromolecules

JF - Biomacromolecules

IS - 1

ER -

Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(Ethylene Glycol) acrylate-based system

Abstract

UN SDGs

Keywords

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