TY - JOUR
T1 - Extrafollicular antibody responses
AU - MacLennan, Ian
AU - Toellner, Kai-Michael
AU - Cunnigham, AF
AU - Serre, Karine
AU - Sze, DMY
AU - Zuniga, E
AU - Cook, MC
PY - 2003/8/1
Y1 - 2003/8/1
N2 - In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.
AB - In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.
UR - http://www.scopus.com/inward/record.url?scp=0038675204&partnerID=8YFLogxK
U2 - 10.1034/j.1600-065X.2003.00058.x
DO - 10.1034/j.1600-065X.2003.00058.x
M3 - Article
C2 - 12846803
SN - 1600-065X
SN - 1600-065X
SN - 1600-065X
SN - 1600-065X
SN - 1600-065X
VL - 194
SP - 8
EP - 18
JO - Immunological Reviews
JF - Immunological Reviews
ER -