Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism

Argyris Zardilis; João Dias; Animesh Acharjee; James Smith

doi:10.1007/978-3-319-12982-2_18

Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism

Argyris Zardilis, João Dias, Animesh Acharjee, James Smith

Cancer and Genomic Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Stochastic reaction-centric views are suitable for exploring hybrid minimal mechanism-statistical models of fatty acid and lipid metabolism, the basis of de novo lipogenesis. In this work, we demonstrate a reduced model for the core fatty acid synthesis and elongation process with a regulatory mechanism. This allows us to explore fatty acid profiles from lipid metabolomics data. This is part of a current study to assess the programming languages for capturing inherent probabilistic behaviour of the hierarchical chemical transformations of complex lipid species.

Original language	English
Title of host publication	Computational Methods in Systems Biology
Subtitle of host publication	12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings
Editors	Pedro Mendes, Joseph O. Dada, Kieran Smallbone
Publisher	Springer
Pages	244–247
Number of pages	4
Edition	1
ISBN (Electronic)	9783319129822
ISBN (Print)	9783319129815
DOIs	https://doi.org/10.1007/978-3-319-12982-2_18
Publication status	Published - 27 Oct 2014
Event	Computational Methods in Systems Biology: 12th International Conference - Manchester, United Kingdom Duration: 17 Nov 2014 → 19 Nov 2014

Publication series

Name	Lecture Notes in Computer Science
Publisher	Springer
Volume	8859
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	Computational Methods in Systems Biology
Abbreviated title	CMSB 2014
Country/Territory	United Kingdom
City	Manchester
Period	17/11/14 → 19/11/14

Access to Document

10.1007/978-3-319-12982-2_18

Cite this

Zardilis, A., Dias, J., Acharjee, A., & Smith, J. (2014). Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism. In P. Mendes, J. O. Dada, & K. Smallbone (Eds.), Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings (1 ed., pp. 244–247). (Lecture Notes in Computer Science; Vol. 8859). Springer. https://doi.org/10.1007/978-3-319-12982-2_18

Zardilis, Argyris ; Dias, João ; Acharjee, Animesh et al. / Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism. Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings. editor / Pedro Mendes ; Joseph O. Dada ; Kieran Smallbone. 1. ed. Springer, 2014. pp. 244–247 (Lecture Notes in Computer Science).

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title = "Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism",

abstract = "Stochastic reaction-centric views are suitable for exploring hybrid minimal mechanism-statistical models of fatty acid and lipid metabolism, the basis of de novo lipogenesis. In this work, we demonstrate a reduced model for the core fatty acid synthesis and elongation process with a regulatory mechanism. This allows us to explore fatty acid profiles from lipid metabolomics data. This is part of a current study to assess the programming languages for capturing inherent probabilistic behaviour of the hierarchical chemical transformations of complex lipid species.",

author = "Argyris Zardilis and Jo{\~a}o Dias and Animesh Acharjee and James Smith",

year = "2014",

month = oct,

day = "27",

doi = "10.1007/978-3-319-12982-2_18",

language = "English",

isbn = "9783319129815",

series = "Lecture Notes in Computer Science",

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pages = "244–247",

editor = "Pedro Mendes and Dada, {Joseph O.} and Kieran Smallbone",

booktitle = "Computational Methods in Systems Biology",

edition = "1",

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Zardilis, A, Dias, J, Acharjee, A & Smith, J 2014, Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism. in P Mendes, JO Dada & K Smallbone (eds), Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings. 1 edn, Lecture Notes in Computer Science, vol. 8859, Springer, pp. 244–247, Computational Methods in Systems Biology, Manchester, United Kingdom, 17/11/14. https://doi.org/10.1007/978-3-319-12982-2_18

Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism. / Zardilis, Argyris; Dias, João; Acharjee, Animesh et al.
Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings. ed. / Pedro Mendes; Joseph O. Dada; Kieran Smallbone. 1. ed. Springer, 2014. p. 244–247 (Lecture Notes in Computer Science; Vol. 8859).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism

AU - Zardilis, Argyris

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AU - Acharjee, Animesh

AU - Smith, James

PY - 2014/10/27

Y1 - 2014/10/27

N2 - Stochastic reaction-centric views are suitable for exploring hybrid minimal mechanism-statistical models of fatty acid and lipid metabolism, the basis of de novo lipogenesis. In this work, we demonstrate a reduced model for the core fatty acid synthesis and elongation process with a regulatory mechanism. This allows us to explore fatty acid profiles from lipid metabolomics data. This is part of a current study to assess the programming languages for capturing inherent probabilistic behaviour of the hierarchical chemical transformations of complex lipid species.

AB - Stochastic reaction-centric views are suitable for exploring hybrid minimal mechanism-statistical models of fatty acid and lipid metabolism, the basis of de novo lipogenesis. In this work, we demonstrate a reduced model for the core fatty acid synthesis and elongation process with a regulatory mechanism. This allows us to explore fatty acid profiles from lipid metabolomics data. This is part of a current study to assess the programming languages for capturing inherent probabilistic behaviour of the hierarchical chemical transformations of complex lipid species.

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DO - 10.1007/978-3-319-12982-2_18

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SN - 9783319129815

T3 - Lecture Notes in Computer Science

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EP - 247

BT - Computational Methods in Systems Biology

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T2 - Computational Methods in Systems Biology

Y2 - 17 November 2014 through 19 November 2014

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Zardilis A, Dias J, Acharjee A, Smith J. Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism. In Mendes P, Dada JO, Smallbone K, editors, Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings. 1 ed. Springer. 2014. p. 244–247. (Lecture Notes in Computer Science). Epub 2014 Oct 20. doi: 10.1007/978-3-319-12982-2_18

Extensible and Executable Stochastic Models of Fatty Acid and Lipid Metabolism

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