Exploring the relationship between cocrystal stability and symmetry: Is Wallach's rule applicable to multi-component solids?

Tomislav Friščić; László Fábián; Jonathan C. Burley; David G. Reid; Melinda J. Duer; William Jones

doi:10.1039/b717532a

Exploring the relationship between cocrystal stability and symmetry: Is Wallach's rule applicable to multi-component solids?

Tomislav Friščić
, László Fábián
, Jonathan C. Burley
, David G. Reid
, Melinda J. Duer
, William Jones^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

Original language	English
Pages (from-to)	1644-1646
Number of pages	3
Journal	Chemical Communications
Issue number	14
DOIs	https://doi.org/10.1039/b717532a
Publication status	Published - 2008

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b717532a

Cite this

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title = "Exploring the relationship between cocrystal stability and symmetry: Is Wallach's rule applicable to multi-component solids?",

abstract = "Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.",

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T2 - Is Wallach's rule applicable to multi-component solids?

AU - Friščić, Tomislav

AU - Fábián, László

AU - Burley, Jonathan C.

AU - Reid, David G.

AU - Duer, Melinda J.

AU - Jones, William

PY - 2008

Y1 - 2008

N2 - Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

AB - Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

UR - https://www.scopus.com/pages/publications/41149161115

U2 - 10.1039/b717532a

DO - 10.1039/b717532a

M3 - Article

C2 - 18368151

AN - SCOPUS:41149161115

SN - 1359-7345

SP - 1644

EP - 1646

JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

Exploring the relationship between cocrystal stability and symmetry: Is Wallach's rule applicable to multi-component solids?

Abstract

ASJC Scopus subject areas

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