Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective

Alexandra Sinclair, Alexandra Ball, Michael Burdon, Carl Clarke, Paul Stewart, Stephen Curnow, Saaeha Rauz

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.
Original languageEnglish
Pages (from-to)212-220
Number of pages9
JournalJournal of Neuroimmunology
Volume201-202
DOIs
Publication statusPublished - 15 Sep 2008

Keywords

  • Obesity
  • 11 beta-hydroxysteroid dehydrogenase
  • Idiopathic intracranial hypertension
  • Chronic inflammation

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