Projects per year
Abstract
Physical activity or regular exercise provides many beneficial effects towards human health, helping prevent and ameliorate metabolic diseases. However, certain molecular mechanisms that mediate these health benefits remain poorly understood. Parker et al. provided the first global analysis of exercise-regulated ubiquitin signalling in human skeletal muscle, revealing post-translational modification cross-talk. As a result of their analysis, NEDDylation is thought to promote ubiquitin signalling for the removal of damaged proteins following exercise. The proteomic dataset generated from their study is invaluable for researchers in this field to validate new mechanistic hypotheses. To further reveal molecular mechanisms regulated by exercise, future research could employ more sensitive mass spectrometry-based workflows that increase the detection of both ubiquitylated sites and peptides and subsequently identify more exercise-regulated ubiquitin signalling pathways.
Original language | English |
---|---|
Pages (from-to) | 402-407 |
Number of pages | 6 |
Journal | FASEB BioAdvances |
Volume | 4 |
Issue number | 6 |
Early online date | 19 Feb 2022 |
DOIs | |
Publication status | Published - Jun 2022 |
Bibliographical note
©2022 The Authors FASEB BioAdvances published by The Federation of American Societies for Experimental Biology.Keywords
- NEDDylation
- mass spectrometry
- physical activity
- ubiquitylation
- ubiquitylome
Fingerprint
Dive into the research topics of 'Exercise mediates ubiquitin signalling in human skeletal muscle'. Together they form a unique fingerprint.Projects
- 1 Finished
-
MRC - ARUK Centre for Musculoskeletal Ageing Research
Jones, S. (Co-Investigator), Buckley, C. (Co-Investigator), Lord, J. (Principal Investigator), Greig, C. (Co-Investigator) & Raza, K. (Co-Investigator)
1/10/17 → 30/06/23
Project: Research Councils