Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest

K Kiilerich, S Ringholm, RS Bienso, James Fisher, N Iversen, G van Hall, JFP Wojtaszewski, B Saltin, C Lundby, JAL Calbet, H Pilegaard

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Abstract

Kiilerich K, Ringholm S, Bienso RS, Fisher JP, Iversen N, van Hall G, Wojtaszewski JF, Saltin B, Lundby C, Calbet JA, Pilegaard H. Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. J Appl Physiol 111: 751-757, 2011. First published June 16, 2011; doi: 10.1152/japplphysiol.00063.2011.-To test the hypothesis that physical inactivity impairs the exercise-induced modulation of pyruvate dehydrogenase (PDH), six healthy normally physically active male subjects completed 7 days of bed rest. Before and immediately after the bed rest, the subjects completed an oral glucose tolerance test (OGTT) and a one-legged knee extensor exercise bout [45 min at 60% maximal load (W-max)] with muscle biopsies obtained from vastus lateralis before, immediately after exercise, and at 3 h of recovery. Blood samples were taken from the femoral vein and artery before and after 40 min of exercise. Glucose intake elicited a larger (P
Original languageEnglish
Pages (from-to)751-757
Number of pages7
JournalJournal of Applied Physiology
Volume111
Issue number3
DOIs
Publication statusPublished - 1 Sep 2011

Keywords

  • PDH
  • physical inactivity
  • human skeletal muscle
  • glucose intolerance

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