Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews

Grace Dibben; Lucy Gardiner; Hannah M.L. Young; Valerie Wells; Rachael A. Evans; Zahira Ahmed; Shaun Barber; Sarah Dean; Patrick Doherty; Nikki Gardiner; Colin Greaves; Tracy Ibbotson; Bhautesh D. Jani; Kate Jolly; Frances S. Mair; Emma McIntosh; Paula Ormandy; Sharon A. Simpson; Sayem Armed; Stefanie J. Krauth; Lewis Steell; Sally J. Singh; Rod S. Taylor

doi:10.1016/j.eclinm.2024.102599

Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews

Grace Dibben^*, Lucy Gardiner, Hannah M.L. Young, Valerie Wells, Rachael A. Evans, Zahira Ahmed, Shaun Barber, Sarah Dean, Patrick Doherty, Nikki Gardiner, Colin Greaves, Tracy Ibbotson, Bhautesh D. Jani, Kate Jolly, Frances S. Mair, Emma McIntosh, Paula Ormandy, Sharon A. Simpson, Sayem Armed, Stefanie J. KrauthLewis Steell, Sally J. Singh, Rod S. Taylor

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

148 Downloads (Pure)

Abstract

Background: Almost half of the global population face significant challenges from long-term conditions (LTCs) resulting in substantive health and socioeconomic burden. Exercise is a potentially key intervention in effective LTC management.

Methods: In this overview of systematic reviews (SRs), we searched six electronic databases from January 2000 to October 2023 for SRs assessing health outcomes (mortality, hospitalisation, exercise capacity, disability, frailty, health-related quality of life (HRQoL), and physical activity) related to exercise-based interventions in adults (aged >18 years) diagnosed with one of 45 LTCs. Methodological quality was assessed using AMSTAR-2. International Prospective Resister of Systematic Reviews (PROSPERO) ID: CRD42022319214.

Findings: Forty-two SRs plus three supplementary RCTs were included, providing 990 RCTs in 936,825 people across 39 LTCs. No evidence was identified for six LTCs. Predominant outcome domains were HRQoL (82% of SRs/RCTs) and exercise capacity (66%); whereas disability, mortality, physical activity, and hospitalisation were less frequently reported (≤25%). Evidence supporting exercise-based interventions was identified in 25 LTCs, was unclear for 13 LTCs, and for one LTC suggested no effect. No SRs considered multimorbidity in the delivery of exercise. Methodological quality varied: critically-low (33%), low (26%), moderate (26%), and high (12%).

Interpretation: Exercise-based interventions improve HRQoL and exercise capacity across numerous LTCs. Key evidence gaps included limited mortality and hospitalisation data and consideration of multimorbidity impact on exercise-based interventions.

Funding: This study was funded by the National Institute for Health and Care Research (NIHR; Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)—NIHR202020).

Original language	English
Article number	102599
Journal	EClinicalMedicine
Volume	72
Early online date	30 Apr 2024
DOIs	https://doi.org/10.1016/j.eclinm.2024.102599
Publication status	Published - Jun 2024

Bibliographical note

Keywords

Long-term conditions
Exercise
Physical activity
Systematic review
Overview

Access to Document

10.1016/j.eclinm.2024.102599Licence: Creative Commons: Attribution (CC BY)

DibbenG2024EvidenceProof, 875 KBLicence: Creative Commons: Attribution (CC BY)

Cite this

Dibben, G., Gardiner, L., Young, H. M. L., Wells, V., Evans, R. A., Ahmed, Z., Barber, S., Dean, S., Doherty, P., Gardiner, N., Greaves, C., Ibbotson, T., Jani, B. D., Jolly, K., Mair, F. S., McIntosh, E., Ormandy, P., Simpson, S. A., Armed, S., ... Taylor, R. S. (2024). Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews. EClinicalMedicine, 72, Article 102599. https://doi.org/10.1016/j.eclinm.2024.102599

@article{7d93003df03045fbb05d3d3bafe3c10c,

title = "Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews",

abstract = "Background: Almost half of the global population face significant challenges from long-term conditions (LTCs) resulting in substantive health and socioeconomic burden. Exercise is a potentially key intervention in effective LTC management.Methods: In this overview of systematic reviews (SRs), we searched six electronic databases from January 2000 to October 2023 for SRs assessing health outcomes (mortality, hospitalisation, exercise capacity, disability, frailty, health-related quality of life (HRQoL), and physical activity) related to exercise-based interventions in adults (aged >18 years) diagnosed with one of 45 LTCs. Methodological quality was assessed using AMSTAR-2. International Prospective Resister of Systematic Reviews (PROSPERO) ID: CRD42022319214.Findings: Forty-two SRs plus three supplementary RCTs were included, providing 990 RCTs in 936,825 people across 39 LTCs. No evidence was identified for six LTCs. Predominant outcome domains were HRQoL (82% of SRs/RCTs) and exercise capacity (66%); whereas disability, mortality, physical activity, and hospitalisation were less frequently reported (≤25%). Evidence supporting exercise-based interventions was identified in 25 LTCs, was unclear for 13 LTCs, and for one LTC suggested no effect. No SRs considered multimorbidity in the delivery of exercise. Methodological quality varied: critically-low (33%), low (26%), moderate (26%), and high (12%).Interpretation: Exercise-based interventions improve HRQoL and exercise capacity across numerous LTCs. Key evidence gaps included limited mortality and hospitalisation data and consideration of multimorbidity impact on exercise-based interventions.Funding: This study was funded by the National Institute for Health and Care Research (NIHR; Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)—NIHR202020).",

keywords = "Long-term conditions, Exercise, Physical activity, Systematic review, Overview",

author = "Grace Dibben and Lucy Gardiner and Young, {Hannah M.L.} and Valerie Wells and Evans, {Rachael A.} and Zahira Ahmed and Shaun Barber and Sarah Dean and Patrick Doherty and Nikki Gardiner and Colin Greaves and Tracy Ibbotson and Jani, {Bhautesh D.} and Kate Jolly and Mair, {Frances S.} and Emma McIntosh and Paula Ormandy and Simpson, {Sharon A.} and Sayem Armed and Krauth, {Stefanie J.} and Lewis Steell and Singh, {Sally J.} and Taylor, {Rod S.}",

note = "{\textcopyright} 2024 The Authors.",

year = "2024",

month = jun,

doi = "10.1016/j.eclinm.2024.102599",

language = "English",

volume = "72",

journal = "EClinicalMedicine",

issn = "2589-5370",

publisher = "Elsevier",

}

Dibben, G, Gardiner, L, Young, HML, Wells, V, Evans, RA, Ahmed, Z, Barber, S, Dean, S, Doherty, P, Gardiner, N, Greaves, C, Ibbotson, T, Jani, BD, Jolly, K, Mair, FS, McIntosh, E, Ormandy, P, Simpson, SA, Armed, S, Krauth, SJ, Steell, L, Singh, SJ & Taylor, RS 2024, 'Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews', EClinicalMedicine, vol. 72, 102599. https://doi.org/10.1016/j.eclinm.2024.102599

TY - JOUR

T1 - Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions

T2 - An Overview of Systematic Reviews

AU - Dibben, Grace

AU - Gardiner, Lucy

AU - Young, Hannah M.L.

AU - Wells, Valerie

AU - Evans, Rachael A.

AU - Ahmed, Zahira

AU - Barber, Shaun

AU - Dean, Sarah

AU - Doherty, Patrick

AU - Gardiner, Nikki

AU - Greaves, Colin

AU - Ibbotson, Tracy

AU - Jani, Bhautesh D.

AU - Jolly, Kate

AU - Mair, Frances S.

AU - McIntosh, Emma

AU - Ormandy, Paula

AU - Simpson, Sharon A.

AU - Armed, Sayem

AU - Krauth, Stefanie J.

AU - Steell, Lewis

AU - Singh, Sally J.

AU - Taylor, Rod S.

PY - 2024/6

Y1 - 2024/6

N2 - Background: Almost half of the global population face significant challenges from long-term conditions (LTCs) resulting in substantive health and socioeconomic burden. Exercise is a potentially key intervention in effective LTC management.Methods: In this overview of systematic reviews (SRs), we searched six electronic databases from January 2000 to October 2023 for SRs assessing health outcomes (mortality, hospitalisation, exercise capacity, disability, frailty, health-related quality of life (HRQoL), and physical activity) related to exercise-based interventions in adults (aged >18 years) diagnosed with one of 45 LTCs. Methodological quality was assessed using AMSTAR-2. International Prospective Resister of Systematic Reviews (PROSPERO) ID: CRD42022319214.Findings: Forty-two SRs plus three supplementary RCTs were included, providing 990 RCTs in 936,825 people across 39 LTCs. No evidence was identified for six LTCs. Predominant outcome domains were HRQoL (82% of SRs/RCTs) and exercise capacity (66%); whereas disability, mortality, physical activity, and hospitalisation were less frequently reported (≤25%). Evidence supporting exercise-based interventions was identified in 25 LTCs, was unclear for 13 LTCs, and for one LTC suggested no effect. No SRs considered multimorbidity in the delivery of exercise. Methodological quality varied: critically-low (33%), low (26%), moderate (26%), and high (12%).Interpretation: Exercise-based interventions improve HRQoL and exercise capacity across numerous LTCs. Key evidence gaps included limited mortality and hospitalisation data and consideration of multimorbidity impact on exercise-based interventions.Funding: This study was funded by the National Institute for Health and Care Research (NIHR; Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)—NIHR202020).

AB - Background: Almost half of the global population face significant challenges from long-term conditions (LTCs) resulting in substantive health and socioeconomic burden. Exercise is a potentially key intervention in effective LTC management.Methods: In this overview of systematic reviews (SRs), we searched six electronic databases from January 2000 to October 2023 for SRs assessing health outcomes (mortality, hospitalisation, exercise capacity, disability, frailty, health-related quality of life (HRQoL), and physical activity) related to exercise-based interventions in adults (aged >18 years) diagnosed with one of 45 LTCs. Methodological quality was assessed using AMSTAR-2. International Prospective Resister of Systematic Reviews (PROSPERO) ID: CRD42022319214.Findings: Forty-two SRs plus three supplementary RCTs were included, providing 990 RCTs in 936,825 people across 39 LTCs. No evidence was identified for six LTCs. Predominant outcome domains were HRQoL (82% of SRs/RCTs) and exercise capacity (66%); whereas disability, mortality, physical activity, and hospitalisation were less frequently reported (≤25%). Evidence supporting exercise-based interventions was identified in 25 LTCs, was unclear for 13 LTCs, and for one LTC suggested no effect. No SRs considered multimorbidity in the delivery of exercise. Methodological quality varied: critically-low (33%), low (26%), moderate (26%), and high (12%).Interpretation: Exercise-based interventions improve HRQoL and exercise capacity across numerous LTCs. Key evidence gaps included limited mortality and hospitalisation data and consideration of multimorbidity impact on exercise-based interventions.Funding: This study was funded by the National Institute for Health and Care Research (NIHR; Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)—NIHR202020).

KW - Long-term conditions

KW - Exercise

KW - Physical activity

KW - Systematic review

KW - Overview

U2 - 10.1016/j.eclinm.2024.102599

DO - 10.1016/j.eclinm.2024.102599

M3 - Review article

C2 - 39010975

SN - 2589-5370

VL - 72

JO - EClinicalMedicine

JF - EClinicalMedicine

M1 - 102599

ER -

Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this