Evaluating the IgMi mouse as a novel tool to study B-cell biology

Rinal Sahputra, Juan Carlos Yam-Puc, Ari Waisman, Werner Muller, Kathryn J Else

Research output: Contribution to journalLetterpeer-review

2 Citations (Scopus)


The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

Original languageEnglish
Pages (from-to)2068-2071
Number of pages4
JournalEuropean Journal of Immunology
Issue number12
Early online date13 Oct 2018
Publication statusPublished - Dec 2018

Bibliographical note

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


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