Evaluating the IgMi mouse as a novel tool to study B-cell biology

Rinal Sahputra; Juan Carlos Yam-Puc; Ari Waisman; Werner Muller; Kathryn J Else

doi:10.1002/eji.201847735

Evaluating the IgMi mouse as a novel tool to study B-cell biology

Rinal Sahputra, Juan Carlos Yam-Puc, Ari Waisman, Werner Muller, Kathryn J Else

Immunology and Immunotherapy

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Abstract

The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and T_FH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

Original language	English
Pages (from-to)	2068-2071
Number of pages	4
Journal	European Journal of Immunology
Volume	48
Issue number	12
Early online date	13 Oct 2018
DOIs	https://doi.org/10.1002/eji.201847735
Publication status	Published - Dec 2018

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title = "Evaluating the IgMi mouse as a novel tool to study B-cell biology",

abstract = "The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.",

author = "Rinal Sahputra and Yam-Puc, {Juan Carlos} and Ari Waisman and Werner Muller and Else, {Kathryn J}",

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AU - Yam-Puc, Juan Carlos

AU - Waisman, Ari

AU - Muller, Werner

AU - Else, Kathryn J

PY - 2018/12

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AB - The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and TFH cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody.

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DO - 10.1002/eji.201847735

M3 - Letter

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JO - European Journal of Immunology

JF - European Journal of Immunology

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Evaluating the IgMi mouse as a novel tool to study B-cell biology

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