Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives

Daniel T. Payne, Yiming Zhao, John S. Fossey

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
171 Downloads (Pure)

Abstract

Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11–67% yield from aldehydes. Aldehydes were reacted with Meldrum’s acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.
Original languageEnglish
Article number1720
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 11 May 2017

Keywords

  • Synthetic chemistry methodology
  • Structure elucidation

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