Establishment and functioning of intrathymic microenvironments

Graham Anderson; William Jenkinson; T Jones; Sonia Parnell; Francesca Kinsella; Andrea White; JE Pongrac'z; Simona Rossi; Eric Jenkinson

doi:10.1111/j.0105-2896.2006.00347.x

Establishment and functioning of intrathymic microenvironments

Graham Anderson, William Jenkinson, T Jones, Sonia Parnell, Francesca Kinsella, Andrea White, JE Pongrac'z, Simona Rossi, Eric Jenkinson

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

Original language	English
Pages (from-to)	10-27
Journal	Immunological Reviews
Volume	209
Issue number	1
DOIs	https://doi.org/10.1111/j.0105-2896.2006.00347.x
Publication status	Published - 28 Jan 2006

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10.1111/j.0105-2896.2006.00347.x

MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)
Jenkinson, E.
Medical Research Council
3/08/09 → 30/09/17
Project: Research Councils

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AU - Parnell, Sonia

AU - Kinsella, Francesca

AU - White, Andrea

AU - Pongrac'z, JE

AU - Rossi, Simona

AU - Jenkinson, Eric

PY - 2006/1/28

Y1 - 2006/1/28

N2 - The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

AB - The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.

UR - http://europepmc.org/abstract/med/16448531

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JO - Immunological Reviews

JF - Immunological Reviews

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Establishment and functioning of intrathymic microenvironments

Abstract

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Projects

MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)

Cite this