Projects per year
Abstract
The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.
Original language | English |
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Pages (from-to) | 10-27 |
Journal | Immunological Reviews |
Volume | 209 |
Issue number | 1 |
DOIs | |
Publication status | Published - 28 Jan 2006 |
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Dive into the research topics of 'Establishment and functioning of intrathymic microenvironments'. Together they form a unique fingerprint.Projects
- 1 Finished
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MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)
Jenkinson, E. (Principal Investigator)
3/08/09 → 30/09/17
Project: Research Councils