Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: Head and neck 5000

Andrew Robert Ness*, Andrea Waylen, Katrina Hurley, Mona Jeffreys, Chris Penfold, Miranda Pring, Sam Leary, Christine Allmark, Stu Toms, Susan Ring, Tim J. Peters, Will Hollingworth, Helen Worthington, Chris Nutting, Sheila Fisher, Simon N. Rogers, Simon Rogers, J. K. Thiruchelvam, Maged Abdelkader, Shahram AnariHisham Mehanna, Tom Sheehan, Karen Dyker, James McCaul, Richard Benson, Simon Stewart, Charles Hall, Jim Lester, Jarrod Homer, Abdel Hamid, Alan Lamont, Lydia Fresco, Shane Lester, Geoffrey Cogill, Amy Roy, Bernie Foran, Brian Bisase, Alistair Balfour, Andrew Evans, Simon Gollins, David Conway, Sinnappa P. Gunasekaran, Laura Lees, Rachel Lowe, James England, Christopher Scrase, Richard Wight, Mehmet Sen, Margret Doyle, Russell Moule, Kate Goodchild, Nick Rowell, Dawn Beaumont-Jewell, H. W. Loo, Petra Jankowska, Vinidh Paleri, Richard Casasola, Tom Roques, Paul Tierney, David Hwang, P. Dyson, Gerard Andrade, Taran Tatla, Judith Christian, Stuart Winter, Andrew Baldwin, Joe Davies, Emma King, Debi Barnes, Costas Repanos, Dae Kim, Stuart Richards, Nicola Dallas, Ken McAlister, Sandeep Berry, Naomi Cole, Laura Moss, Nachi Palaniappan, Mererid Evans, Muthu Siva, Churunal Hari, Katie Wood, Richard Simcock, John Waldron, Nicholas Hyde, Imtiaz Ahmed, Daljit Gahir, James O'Hara, Ruth Carr, Martin Forster, Steve Thomas, Lynda Wagstaff, Joseph Mano, Caroline Brammer, Jayne Tyler, Andrew Coatesworth, Steve Thomas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors.

METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires.

DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

Original languageEnglish
Article number973
Pages (from-to)973
JournalBMC Cancer
Issue number1
Publication statusPublished - 17 Dec 2014


  • Data Collection
  • Great Britain
  • Head and Neck Neoplasms
  • Humans
  • Informed Consent
  • Life Style
  • Longitudinal Studies
  • Medical Record Linkage
  • Patient Selection
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • Sexual Behavior
  • Surveys and Questionnaires
  • Translational Medical Research

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics


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