Essentials in the use of mycolic acid biomarkers for tuberculosis detection: response to "High-throughput mass spectrometric analysis of 1400-year-old mycolic acids as biomarkers for ancient tuberculosis infection" by Mark et al., 2010

David Minnikin, Oona Lee, M Pitts, MS Baird, Gurdyal Besra

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

High molecular weight long-chain mycolic acids are key structural components of the cell envelope of Mycobacterium tuberculosis and they are established as biomarkers for the identification of both ancient and modern tuberculosis. Mycolic acids from M. tuberculosis have a characteristic profile, reflecting contributions from five major distinct homologous series of mycolate structural types. Diagnosis of tuberculosis in archaeological material, using mycolic acid biomarkers, depends on objective recognition of the key characteristic mycolic acid components. A recent article in this journal claimed that tuberculosis could be confirmed in ancient bones by high throughput mass spectrometric analysis of mycolic acids. Scrutiny of the data presented reveals no convincing evidence for the presence of mycolic acids, characteristic of the M. tuberculosis complex, in the skeletal remains examined. This communication reviews the essential criteria necessary for positive tuberculosis diagnosis, using mycolic acids. (C) 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2407-2412
Number of pages6
JournalJournal of Archaeological Science
Volume37
Issue number10
DOIs
Publication statusPublished - 1 Oct 2010

Keywords

  • Mass spectrometry
  • Archaeology
  • Tuberculosis
  • Biomarkers
  • Paleopathology
  • Mycolic acids
  • Mycobacterium tuberculosis

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