EspF of enteropathogenic Escherichia coli binds sorting nexin 9

O Marches; M Batchelor; Robert Shaw; A Patel; N Cummings; T Nagai; C Sasakawa; SR Carlsson; R Lundmark; C Cougoule; E Caron; Stuart Knutton; I Connerton; G Frankel

doi:10.1128/JB.188.8.3110-3115.2006

EspF of enteropathogenic Escherichia coli binds sorting nexin 9

O Marches
, M Batchelor
, Robert Shaw
, A Patel
, N Cummings
, T Nagai
, C Sasakawa
, SR Carlsson
, R Lundmark
, C Cougoule
, E Caron
, Stuart Knutton
, I Connerton
, G Frankel

Biosciences

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and nonmitochondrial protein colocalization in infected epithelial cells.

Original language	English
Pages (from-to)	3110-3115
Number of pages	6
Journal	Journal of Bacteriology
Volume	188
Issue number	8
DOIs	https://doi.org/10.1128/JB.188.8.3110-3115.2006
Publication status	Published - 1 Apr 2006

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10.1128/JB.188.8.3110-3115.2006

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title = "EspF of enteropathogenic Escherichia coli binds sorting nexin 9",

abstract = "EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and nonmitochondrial protein colocalization in infected epithelial cells.",

author = "O Marches and M Batchelor and Robert Shaw and A Patel and N Cummings and T Nagai and C Sasakawa and SR Carlsson and R Lundmark and C Cougoule and E Caron and Stuart Knutton and I Connerton and G Frankel",

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doi = "10.1128/JB.188.8.3110-3115.2006",

language = "English",

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TY - JOUR

T1 - EspF of enteropathogenic Escherichia coli binds sorting nexin 9

AU - Marches, O

AU - Batchelor, M

AU - Shaw, Robert

AU - Patel, A

AU - Cummings, N

AU - Nagai, T

AU - Sasakawa, C

AU - Carlsson, SR

AU - Lundmark, R

AU - Cougoule, C

AU - Caron, E

AU - Knutton, Stuart

AU - Connerton, I

AU - Frankel, G

PY - 2006/4/1

Y1 - 2006/4/1

N2 - EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and nonmitochondrial protein colocalization in infected epithelial cells.

AB - EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and nonmitochondrial protein colocalization in infected epithelial cells.

U2 - 10.1128/JB.188.8.3110-3115.2006

DO - 10.1128/JB.188.8.3110-3115.2006

M3 - Article

C2 - 16585770

VL - 188

SP - 3110

EP - 3115

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 8

ER -

EspF of enteropathogenic Escherichia coli binds sorting nexin 9

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