Abstract
Since 'constitutive activation' Of STAT1 was first described in Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs), there has been controversy regarding the molecular identity of the STAT1 DNA-binding complex found in these cells. The post-translational modifications of STAT1 in LCLs have been analysed and an LMP1-induced STAT1 DNA-binding complex, different from that generated by alpha interferon (IFN) stimulation and not involving tyrosine phosphorylation, is demonstrated. STAT1 is serine-phosphorylated downstream of Pl3K and MEK in LCLs and this modification restricts IFN-stimulated STAT1 -DNA binding. These data suggest that EBV induces a distinct form of DNA-bound STAT1 in virus-infected cells.
Original language | English |
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Pages (from-to) | 1876-1886 |
Number of pages | 11 |
Journal | Journal of General Virology |
Volume | 88 |
DOIs | |
Publication status | Published - 1 Jul 2007 |