Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells

Christopher Fox; Claire Shannon-Lowe; P Gothard; B Kishore; J Neilson; N O'Connor; Martin Rowe

doi:10.1086/653424

Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells

Christopher Fox, Claire Shannon-Lowe, P Gothard, B Kishore, J Neilson, N O'Connor, Martin Rowe

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

Original language	English
Pages (from-to)	66-69
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	51
Issue number	1
DOIs	https://doi.org/10.1086/653424
Publication status	Published - 1 Jul 2010

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10.1086/653424

Optimising T Cell Immunotherapeutic Strategies for T/NK Cell Lymphomas Associated with Epstein-Barr Virus
Rowe, M.
GUYS & ST THOMAS CHARITY
1/01/09 → 31/12/10
Project: Research
Epstein-Barr Virus Infections of B Lymphocytes and the Pathogenesis of Virus-Associated Lymphomas
Rickinson, A., Bell, A. & Rowe, M.
Cancer Research UK
1/01/08 → 31/12/12
Project: Research
In vitro and In vivo Studies on Epstein Barr Virus Infections Relevant to the Pathogenesis of NK Cell Lymphoma/Leukaemia
Rowe, M. & Rickinson, A.
GUYS & ST THOMAS CHARITY, BLOODWISE
10/09/07 → 9/12/10
Project: Research

Cite this

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title = "Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells",

abstract = "Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.",

author = "Christopher Fox and Claire Shannon-Lowe and P Gothard and B Kishore and J Neilson and N O'Connor and Martin Rowe",

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AU - Fox, Christopher

AU - Shannon-Lowe, Claire

AU - Gothard, P

AU - Kishore, B

AU - Neilson, J

AU - O'Connor, N

AU - Rowe, Martin

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

AB - Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

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DO - 10.1086/653424

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JF - Clinical Infectious Diseases

IS - 1

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Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells

Abstract

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Projects

Optimising T Cell Immunotherapeutic Strategies for T/NK Cell Lymphomas Associated with Epstein-Barr Virus

Epstein-Barr Virus Infections of B Lymphocytes and the Pathogenesis of Virus-Associated Lymphomas

In vitro and In vivo Studies on Epstein Barr Virus Infections Relevant to the Pathogenesis of NK Cell Lymphoma/Leukaemia

Cite this