Epstein-Barr virus and the origin of Hodgkin lymphoma

Martina Vockerodt; Fathima Zumla Cader; Claire Shannon-Lowe; Paul Murray

doi:10.5732/cjc.014.10193

Epstein-Barr virus and the origin of Hodgkin lymphoma

Martina Vockerodt, Fathima Zumla Cader, Claire Shannon-Lowe, Paul Murray

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.

Original language	English
Pages (from-to)	591-7
Number of pages	7
Journal	Chinese Journal of Cancer
Volume	33
Issue number	12
DOIs	https://doi.org/10.5732/cjc.014.10193
Publication status	Published - Dec 2014

Keywords

Epstein-Barr Virus Infections
Herpesvirus 4, Human
Hodgkin Disease
Humans
Reed-Sternberg Cells

UN SDGs

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10.5732/cjc.014.10193

Molecular and Cellular Mechanisms of Synapse-Mediated Spread of Epstein Barr Virus: Overcoming the CD21-Restricted Cellular Tropism
Shannon-Lowe, C. (Principal Investigator)
Medical Research Council
1/09/12 → 29/02/16
Project: Research Councils

Cite this

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title = "Epstein-Barr virus and the origin of Hodgkin lymphoma",

abstract = "Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.",

keywords = "Epstein-Barr Virus Infections, Herpesvirus 4, Human, Hodgkin Disease, Humans, Reed-Sternberg Cells",

author = "Martina Vockerodt and Cader, {Fathima Zumla} and Claire Shannon-Lowe and Paul Murray",

year = "2014",

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doi = "10.5732/cjc.014.10193",

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journal = "Chinese Journal of Cancer",

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AU - Cader, Fathima Zumla

AU - Shannon-Lowe, Claire

AU - Murray, Paul

PY - 2014/12

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AB - Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.

KW - Epstein-Barr Virus Infections

KW - Herpesvirus 4, Human

KW - Hodgkin Disease

KW - Humans

KW - Reed-Sternberg Cells

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DO - 10.5732/cjc.014.10193

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EP - 597

JO - Chinese Journal of Cancer

JF - Chinese Journal of Cancer

IS - 12

ER -

Epstein-Barr virus and the origin of Hodgkin lymphoma

Abstract

Keywords

UN SDGs

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Molecular and Cellular Mechanisms of Synapse-Mediated Spread of Epstein Barr Virus: Overcoming the CD21-Restricted Cellular Tropism

Cite this