Epstein-Barr virus and the origin of Hodgkin lymphoma

Martina Vockerodt, Fathima Zumla Cader, Claire Shannon-Lowe, Paul Murray

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.

Original languageEnglish
Pages (from-to)591-7
Number of pages7
JournalChinese Journal of Cancer
Issue number12
Publication statusPublished - Dec 2014


  • Epstein-Barr Virus Infections
  • Herpesvirus 4, Human
  • Hodgkin Disease
  • Humans
  • Reed-Sternberg Cells


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