Projects per year
Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
- Epstein-Barr Virus Infections
- Herpesvirus 4, Human
- Hodgkin Disease
- Reed-Sternberg Cells
FingerprintDive into the research topics of 'Epstein-Barr virus and the origin of Hodgkin lymphoma'. Together they form a unique fingerprint.
- 1 Finished
Molecular and Cellular Mechanisms of Synapse-Mediated Spread of Epstein Barr Virus: Overcoming the CD21-Restricted Cellular Tropism
1/09/12 → 29/02/16
Project: Research Councils