Epithelial tumours induced by a herpesvirus oncogene in transgenic mice

C. Murphy, C. Kretschmer, B. Biesinger, J. Beckers, J. Jung, R. C. Desrosiers, H. K. Muller-Hermelink, B. W. Fleckenstein, U. Ruther

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To investigate the role of herpesviral genes in tumourigenesis, transgenic mice were generated expressing STP-C, a transformation associated protein of the lymphoma inducing herpesvirus saimiri. Epithelial tumours developed in the salivary gland, pancreas, thymus and liver of transgenic mice within the first weeks of life. Thus, the target cells for tumour formation in the transgenic mice were surprisingly different from those of the herpesvirus from which the oncogene was derived. Our results identify STP-C as a herpesvirus oncogene sufficient for tumour induction without the cooperation of other viral gene products. Furthermore, the results demonstrate pleiotropic transforming capabilities of the STP-C oncogene and suggest that the specificity of lymphoma induction by the virus is determined by factors other than the oncogene itself.
Original languageEnglish
Pages (from-to)221-226
Number of pages6
Publication statusPublished - 1994

Bibliographical note

M1 - 1

Murphy, C Kretschmer, C Biesinger, B Beckers, J Jung, J Desrosiers, R C Muller-Hermelink, H K Fleckenstein, B W Ruther, U eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. ENGLAND 1994/01/01 Oncogene. 1994 Jan;9(1):221-6.


  • Animals Base Sequence *Cell Transformation, Neoplastic Epithelium/pathology Herpesvirus 2, Saimiriine/*genetics Lymphocyte Activation Mice Mice, Transgenic Molecular Sequence Data Neoplasms/*etiology Oncogene Proteins, Viral/*genetics *Oncogenes Phenotype


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