Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin

J Calderón-Amador; A Flores-Langarica; A Silva-Sánchez; L Donis-Maturano; J Granados; E Vega-Memije; R M Lacy-Niebla; T Hojyo-Tomoka; L Dominguez-Soto; L Flores-Romo

doi:10.1111/j.1468-3083.2008.03060.x

Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin

J Calderón-Amador
, A Flores-Langarica
, A Silva-Sánchez
, L Donis-Maturano
, J Granados
, E Vega-Memije
, R M Lacy-Niebla
, T Hojyo-Tomoka
, L Dominguez-Soto
, L Flores-Romo

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.

OBJECTIVE: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo.

STUDY DESIGN: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject.

SETTING: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city.

METHODS: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets.

RESULTS: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated.

CONCLUSION: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.

Original language	English
Pages (from-to)	438-40
Number of pages	3
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1111/j.1468-3083.2008.03060.x
Publication status	Published - Apr 2009

Keywords

Epidermis
Humans
Langerhans Cells
Photosensitivity Disorders
Prurigo
Comparative Study
Journal Article

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10.1111/j.1468-3083.2008.03060.x

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Calderón-Amador, J., Flores-Langarica, A., Silva-Sánchez, A., Donis-Maturano, L., Granados, J., Vega-Memije, E., Lacy-Niebla, R. M., Hojyo-Tomoka, T., Dominguez-Soto, L., & Flores-Romo, L. (2009). Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin. Journal of the European Academy of Dermatology and Venereology, 23(4), 438-40. https://doi.org/10.1111/j.1468-3083.2008.03060.x

@article{91db8fdbfd03484194afa6ad7f06e8ba,

title = "Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin",

abstract = "BACKGROUND: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.OBJECTIVE: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo.STUDY DESIGN: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject.SETTING: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city.METHODS: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets.RESULTS: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated.CONCLUSION: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.",

keywords = "Epidermis, Humans, Langerhans Cells, Photosensitivity Disorders, Prurigo, Comparative Study, Journal Article",

author = "J Calder{\'o}n-Amador and A Flores-Langarica and A Silva-S{\'a}nchez and L Donis-Maturano and J Granados and E Vega-Memije and Lacy-Niebla, \{R M\} and T Hojyo-Tomoka and L Dominguez-Soto and L Flores-Romo",

year = "2009",

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doi = "10.1111/j.1468-3083.2008.03060.x",

language = "English",

volume = "23",

pages = "438--40",

journal = "Journal of the European Academy of Dermatology and Venereology",

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Calderón-Amador, J, Flores-Langarica, A, Silva-Sánchez, A, Donis-Maturano, L, Granados, J, Vega-Memije, E, Lacy-Niebla, RM, Hojyo-Tomoka, T, Dominguez-Soto, L & Flores-Romo, L 2009, 'Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin', Journal of the European Academy of Dermatology and Venereology, vol. 23, no. 4, pp. 438-40. https://doi.org/10.1111/j.1468-3083.2008.03060.x

TY - JOUR

T1 - Epidermal Langerhans cells in Actinic Prurigo

T2 - a comparison between lesional and non-lesional skin

AU - Calderón-Amador, J

AU - Flores-Langarica, A

AU - Silva-Sánchez, A

AU - Donis-Maturano, L

AU - Granados, J

AU - Vega-Memije, E

AU - Lacy-Niebla, R M

AU - Hojyo-Tomoka, T

AU - Dominguez-Soto, L

AU - Flores-Romo, L

PY - 2009/4

Y1 - 2009/4

N2 - BACKGROUND: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.OBJECTIVE: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo.STUDY DESIGN: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject.SETTING: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city.METHODS: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets.RESULTS: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated.CONCLUSION: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.

AB - BACKGROUND: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.OBJECTIVE: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo.STUDY DESIGN: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject.SETTING: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city.METHODS: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets.RESULTS: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated.CONCLUSION: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.

KW - Epidermis

KW - Humans

KW - Langerhans Cells

KW - Photosensitivity Disorders

KW - Prurigo

KW - Comparative Study

KW - Journal Article

U2 - 10.1111/j.1468-3083.2008.03060.x

DO - 10.1111/j.1468-3083.2008.03060.x

M3 - Article

C2 - 19335731

SN - 0926-9959

VL - 23

SP - 438

EP - 440

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

IS - 4

ER -

Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin

Abstract

Keywords

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