Epidermal Langerhans cells in Actinic Prurigo: a comparison between lesional and non-lesional skin

J Calderón-Amador, A Flores-Langarica, A Silva-Sánchez, L Donis-Maturano, J Granados, E Vega-Memije, R M Lacy-Niebla, T Hojyo-Tomoka, L Dominguez-Soto, L Flores-Romo

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1 Citation (Scopus)


BACKGROUND: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.

OBJECTIVE: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo.

STUDY DESIGN: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject.

SETTING: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city.

METHODS: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets.

RESULTS: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated.

CONCLUSION: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.

Original languageEnglish
Pages (from-to)438-40
Number of pages3
JournalJournal of the European Academy of Dermatology and Venereology
Issue number4
Publication statusPublished - Apr 2009


  • Epidermis
  • Humans
  • Langerhans Cells
  • Photosensitivity Disorders
  • Prurigo
  • Comparative Study
  • Journal Article


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