Epidemiology of Acromegaly: Review of population studies

A Lavrentaki, Niki Karavitaki, A Paluzzi, John A H Wass

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)
301 Downloads (Pure)


Acromegaly is a rare condition necessitating large population studies for the generation of reliable epidemiological data. In this review, we systematically analysed the epidemiological profile of this condition based on recently published population studies from various geographical areas. The total prevalence ranges between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates range between 0.2 and 1.1 cases/100,000 people. The median age at diagnosis is in the fifth decade of life with a median diagnostic delay of 4.5-5 years. Acral enlargement and coarse facial features are the most commonly described clinical manifestations. At the time of detection, most of the tumors are macroadenomas possibly relating to diagnostic delays and posing challenges in the surgical management. Increased awareness of acromegaly amongst the medical community is of major importance aiming to reduce the adverse sequelae of late diagnosis and treatment, improve patient outcomes and, hopefully, reduce the burden on the health care system.
Original languageEnglish
Pages (from-to)4–9
Issue number1
Early online date14 Oct 2016
Publication statusPublished - Feb 2017


  • Acromegaly
  • Incidence
  • Prevalence
  • Epidemiology


Dive into the research topics of 'Epidemiology of Acromegaly: Review of population studies'. Together they form a unique fingerprint.

Cite this